PMID: 15245135Jul 13, 2004Paper

Scaling of microtubule force-velocity curves obtained at different tubulin concentrations

Physical Review Letters
Marcel E Janson, Marileen Dogterom

Abstract

We present a single curve that describes the decay in average growth velocity for microtubules in response to a mechanical force. Curves obtained at two new and one previously studied tubulin concentrations coalesce when normalized with the growth velocity at zero load. This scaling provides direct evidence for a force-independent molecular off rate, in agreement with Brownian ratchet models. In addition, microtubule length changes were measured with a precision up to 10 nm, revealing that microtubules under load abruptly switch between different growth velocities.

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Citations

Jun 27, 2006·Nature·Jacob W J KerssemakersMarileen Dogterom
Apr 20, 2005·The Journal of Chemical Physics·Evgeny B Stukalin, Anatoly B Kolomeisky
Dec 27, 2005·The Journal of Chemical Physics·N J Burroughs, D Marenduzzo
Dec 18, 2014·Biophysical Journal·Maria Zeitz, Jan Kierfeld
Mar 19, 2009·Molecular Systems Biology·Dietrich FoethkeFrançois Nédélec
Mar 19, 2009·Molecular Systems Biology·Christian TischerMarileen Dogterom
Nov 21, 2015·Biophysical Journal·Bin Xu, Paul C Bressloff
Sep 30, 2004·Biophysical Journal·Marcel E Janson, Marileen Dogterom
Jan 31, 2006·Biophysical Journal·Evgeny B Stukalin, Anatoly B Kolomeisky
Jun 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Liedewij LaanMarileen Dogterom
Dec 19, 2014·ELife·Jonathan J WardFrançois Nédélec
Feb 23, 2012·Scientific Reports·Francesco DifatoEvelina Chieregatti
Sep 30, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jonathon Howard, Carlos Garzon-Coral
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