Scaling of subcellular actin structures with cell length through decelerated growth.

ELife
S. G. McInallyBruce L Goode

Abstract

How cells tune the size of their subcellular parts to scale with cell size is a fundamental question in cell biology. Until now, most studies on the size control of organelles and other subcellular structures have focused on scaling relationships with cell volume, which can be explained by limiting pool mechanisms. Here, we uncover a distinct scaling relationship with cell length rather than volume, revealed by mathematical modeling and quantitative imaging of yeast actin cables. The extension rate of cables decelerates as they approach the rear of the cell, until cable length matches cell length. Further, the deceleration rate scales with cell length. These observations are quantitatively explained by a 'balance-point' model, which stands in contrast to limiting pool mechanisms, and describes a distinct mode of self-assembly that senses the linear dimensions of the cell.

References

Jan 27, 2000·Cell·M KirschnerT Mitchison
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hyeong-Cheol Yang, Liza A Pon
Sep 17, 2004·Molecular Biology of the Cell·David PruyneAnthony Bretscher
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas GregorEric F Wieschaus
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·James B Moseley, Bruce L Goode
Jun 29, 2007·Molecular Biology of the Cell·Paul JorgensenBruce Futcher
Nov 14, 2007·The Journal of Cell Biology·Frank R Neumann, Paul Nurse
Feb 9, 2010·Current Biology : CB·Garrett GreenanAnthony A Hyman
Oct 16, 2010·Cell·Daniel L Levy, Rebecca Heald
Nov 9, 2010·Current Biology : CB·Martin WührTimothy J Mitchison
Apr 14, 2011·Journal of Cell Science·Jerry H YuRoland Wedlich-Söldner
Aug 2, 2011·Current Biology : CB·Markus DeckerAnthony A Hyman
Aug 16, 2011·Developmental Cell·Melissa Chesarone-CataldoBruce L Goode
Aug 30, 2011·Current Opinion in Genetics & Development·Danny Ben-ZviNaama Barkai
May 12, 2012·Current Biology : CB·Nathan W Goehring, Anthony A Hyman
Nov 10, 2012·Science·Susanne M RafelskiWallace F Marshall
Nov 16, 2013·Science·Matthew C GoodRebecca Heald
Feb 24, 2015·Current Biology : CB·Stephanie C Weber, Clifford P Brangwynne
Jun 25, 2015·PLoS Computational Biology·Lishibanya MohapatraJane Kondev
Aug 9, 2015·Cold Spring Harbor Perspectives in Biology·Simone Reber, Nathan W Goehring
Mar 18, 2016·Molecular Biology of the Cell·Benjamin LacroixAmy S Maddox
May 6, 2016·Annual Review of Biophysics·Lishibanya MohapatraJane Kondev
May 23, 2018·Developmental Cell·Benjamin LacroixJulien Dumont
Dec 24, 2018·PloS One·Corey A H AllardBrian R Graziano
Jan 15, 2019·Cell·Christopher Brownlee, Rebecca Heald
Jun 13, 2020·Nature Communications·I V KukhtevichK M Schmoller
Nov 21, 2020·Current Biology : CB·Elisa Maria RieckhoffJan Brugués
Apr 27, 2021·IScience·David BauerWallace F Marshall

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