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Scaling probabilistic models of genetic variation to millions of humans

Nature Genetics

Nov 8, 2016

Prem GopalanJohn D Storey

Abstract

A major goal of population genetics is to quantitatively understand variation of genetic polymorphisms among individuals. The aggregated number of genotyped humans is currently on the order of millions of individuals, and existing methods do not scale to data of this size. To solve this...read more

Mentioned in this Paper

Biological Markers
Gene Polymorphism
Size
Aggregation
Genetics, Population
Genetic Markers
Structure
Simulation
Two-Parameter Models
Bayesian Prediction
169
4
1
93
Paper Details
References
  • References14
  • Citations4
12

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Scaling probabilistic models of genetic variation to millions of humans

Nature Genetics

Nov 8, 2016

Prem GopalanJohn D Storey

PMID: 27819665

DOI: 10.1038/ng.3710

Abstract

A major goal of population genetics is to quantitatively understand variation of genetic polymorphisms among individuals. The aggregated number of genotyped humans is currently on the order of millions of individuals, and existing methods do not scale to data of this size. To solve this...read more

Mentioned in this Paper

Biological Markers
Gene Polymorphism
Size
Aggregation
Genetics, Population
Genetic Markers
Structure
Simulation
Two-Parameter Models
Bayesian Prediction
169
4
1
93

Feeds With Similar Papers

Structural Biology: Biophysics

Structural Biology: Biophysics describes the study of structural biology using various biophysical techiniques such as imaging, computational modeling, etc. Discover the latest research on structrual biology here.

Related Papers

Annals of Human Genetics

Selecting SNPs to identify ancestry(opens in new tab)

Annals of Human GeneticsJune 15, 2011
Joshua N SampsonHongyu Zhao
IEEE Transactions on Medical Imaging

Probabilistic Modeling of Imaging, Genetics and Diagnosis(opens in new tab)

IEEE Transactions on Medical ImagingFebruary 18, 2016
Nematollah K BatmanghelichPolina Golland
Paper Details
References
  • References14
  • Citations4
12

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