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Scaling properties of evolutionary paths in a biophysical model of protein adaptation

bioRxiv

Oct 6, 2014

Michael Manhart, Alexandre V. Morozov

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Abstract

The enormous size and complexity of genotypic sequence space frequently requires consideration of coarse-grained sequences in empirical models. We develop scaling relations to quantify the effect of this coarse-graining on properties of fitness landscapes and evolutionary paths. We firs...read more

Mentioned in this Paper

Protein Folding
Landscapes
Amino Acid [EPC]
Biophysics
Adaptation
Pathological Fracture
Grains
Size
Protein-Protein Interaction
Dace
8
Paper Details
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  • Scaling properties of evolutionary paths in a biophysical model of protein adaptation

    bioRxiv

    Oct 6, 2014

    Michael Manhart, Alexandre V. Morozov

    PMID: 990010082

    DOI: 10.1101/010082

    Abstract

    The enormous size and complexity of genotypic sequence space frequently requires consideration of coarse-grained sequences in empirical models. We develop scaling relations to quantify the effect of this coarse-graining on properties of fitness landscapes and evolutionary paths. We firs...read more

    Mentioned in this Paper

    Protein Folding
    Landscapes
    Amino Acid [EPC]
    Biophysics
    Adaptation
    8
    Paper Details
    References
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      We're still populating references for this paper, please check back later.
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