Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion.

Pharmaceutical Research
Pia ThyboSune Klint Andersen

Abstract

The purpose of this study was to investigate the possibility of producing identical powders in pilot and production scale spray drying equipment by matching the droplet size distributions produced by two differently sized atomizers. Particles were prepared by spray drying solutions of acetaminophen and polyvinylpyrrolidone K-30. The success of the up-scaling was evaluated by comparing the powders in terms of particle size distribution (laser diffraction), crystallinity (XPRD) and morphology (SEM). Furthermore, the influence of process parameters on other product characteristics such as stability and residual volatile content was also evaluated. The spray drying experiments resulted in spherical, amorphous particles with volumetric median diameters of typically 4-10 microm for pilot scale and 4-30 microm for production scale. The results showed that particles with similar morphology and crystallinity could be produced in the two applied spray dryers. However, scale-up based purely on matching droplet size distributions was not feasible. The scale-up criterion did not account for the differences between the droplet-drying gas mixing and residence time distribution within the two spray dryers. Therefore, production scale experimen...Continue Reading

References

Aug 1, 1995·Journal of Pharmaceutical Sciences·M YoshiokaG Zografi
Aug 1, 1997·Pharmaceutical Development and Technology·Y F MaaC C Hsu
Aug 26, 2000·Chemical & Pharmaceutical Bulletin·P di MartinoS Martelli
Sep 1, 2000·International Journal of Pharmaceutics·A BillonM Jacob
Sep 12, 2000·Journal of Pharmaceutical Sciences·K Khougaz, S D Clas
Nov 10, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P JohansenB Gander
Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G Van den MooterR Kinget
May 2, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Thomas N MastersFrancis Robicsek
Sep 1, 2004·International Journal of Pharmaceutics·Anshuman A AmbikeAnant Paradkar
Sep 2, 2004·Chemical & Pharmaceutical Bulletin·Richer ChenKazumi Danjo
Sep 25, 2004·Journal of Pharmaceutical Sciences·Tamaki MiyazakiShigeo Kojima
Dec 8, 2004·Pharmaceutical Development and Technology·Kristina MosénAnders Axelsson
May 9, 2007·Pharmaceutical Development and Technology·Pia ThyboLars Hovgaard
Apr 2, 2008·Pharmaceutical Development and Technology·Pia ThyboJesper Saederup Lindeløv

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Citations

Sep 30, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·O NuchuchuaW Jiskoot
Jan 31, 2016·Advanced Drug Delivery Reviews·Teófilo VasconcelosBruno Sarmento
Jul 24, 2012·International Journal of Pharmaceutics·Amrit PaudelGuy Van den Mooter
Jan 8, 2016·Pharmaceutical Development and Technology·Moritz Beck-BroichsitterThomas Kissel
Dec 27, 2015·Advanced Drug Delivery Reviews·Abhishek Singh, Guy Van den Mooter
Dec 2, 2010·Advanced Drug Delivery Reviews·Jian ZhangWiwik Watanabe
Sep 1, 2015·Preventive Veterinary Medicine·Peter R Davies
May 3, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Bhavesh B PatelDali Shukla
Mar 11, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Moritz Beck-BroichsitterThomas Kissel
Oct 5, 2014·Veterinary Microbiology·Priscilla F GerberTanja Opriessnig
Apr 21, 2017·Expert Opinion on Drug Delivery·Ali Al-KhattawiDavid Wilson
Mar 18, 2010·Journal of Pharmaceutical Innovation·Dan E DobryRon A Beyerinck
Nov 14, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Lalit BansalSaptarshi Basu
Mar 31, 2021·Annual Review of Chemical and Biomolecular Engineering·John M BaumannJoel D Wood

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