Scalp electroencephalographic biomarkers in epilepsy patients with focal cortical dysplasia

Annals of Neurology
Nino EpitashviliA Schulze-Bonhage

Abstract

To assess scalp electroencephalographic (EEG) patterns as possible biomarkers for an underlying focal cortical dysplasia (FCD) in patients with structural epilepsy. Scalp electroencephalograms (EEGs) of epilepsy patients with histologically confirmed diagnosis of FCD type I or II (n = 71, age = 3-66 years, 28 female) and of controls with other underlying pathologies (n = 43, age = 2-60 years, 16 female) were retrospectively evaluated regarding the presence or absence of 12 scalp EEG patterns previously reported to be associated with FCD. Furthermore, 2 subgroups of these biomarkers with common characteristics were also analyzed. Each of the 12 biomarkers was tested for association with FCD by comparing the presence of each feature in FCD patients and controls using Fisher exact test. A significant association with FCD as underlying etiology was found for 6 of 12 previously reported biomarkers. With decreasing odds ratios, these were continuous epileptiform discharges, 2 types of rhythmic epileptiform discharges, polyspikes, frequent rhythmic bursting epileptiform activity, and repetitive discharges as well as the subgroups containing repetitive activity and polyspikes, respectively. Presence of EEG biomarkers was independent of...Continue Reading

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Citations

Aug 2, 2019·CNS Neuroscience & Therapeutics·Tian-Shuang WangYe Wu
Apr 17, 2020·Annals of Clinical and Translational Neurology·Di WangGuoguang Zhao
Jan 24, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christin M EltzeFrancine Chassoux
Jul 26, 2021·Journal of Neuroscience Methods·Matthias DümpelmannAndreas Schulze-Bonhage

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