Scalp recorded direct current potential shifts associated with the transition to sleep in man

Electroencephalography and Clinical Neurophysiology
L MarshallJ Born

Abstract

Cortical direct current (DC) potentials are considered to reflect the state of cortical excitability which may change characteristically from wakefulness to sleep. The present experiments examined changes in the scalp recorded DC potential in 10 healthy humans at the transition from wakefulness to nocturnal sleep. For each subject, DC recordings obtained from Cz were evaluated for a 15 min pre-sleep onset interval and for a 20 min post-sleep onset interval, on 2 separate nights. Sleep stages were determined from standard sleep recordings. The transition from wakefulness to sleep coincided with a significant (P < 0.05) shift in the DC potential of negative polarity. Maximum negative potentials of (mean +/- S.E.M.) 500 +/- 130 microV (first night) and of 760 +/- 200 microV (second night) were reached at the end of the 20 min post-sleep onset interval. A number of possible technical and biological artifacts were controlled. It is reasonable to assume that the slow negative shift of the DC potential at the transition from wakefulness to sleep reflects increased cortical excitability. Whether the negative potential shift pertains during sleep, or is of transient nature and closely linked to the process of falling asleep, remains to ...Continue Reading

References

Feb 1, 1978·Chest·C Guilleminault
Jun 1, 1989·Electroencephalography and Clinical Neurophysiology·H BauerM Leodolter
Oct 1, 1972·Electroencephalography and Clinical Neurophysiology·T W Picton, S A Hillyard
Jul 1, 1974·Electroencephalography and Clinical Neurophysiology·D G Girton, J Kamiya
Jun 1, 1965·Electroencephalography and Clinical Neurophysiology·R H WURTZ

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Citations

Jul 1, 1996·Electroencephalography and Clinical Neurophysiology·S Tomita-Gotoh, Y Hayashida
Mar 10, 2001·Physiology & Behavior·B SchmittJ Born
Sep 30, 1998·The European Journal of Neuroscience·L MarshallJ Born
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P TallgrenJ Voipio
Mar 4, 2003·Journal of Neurophysiology·Juha VoipioKai Kaila

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