Apr 9, 2020

New Insights Into the Effect of Residue Mutation on the Rotavirus VP1 Function Using Molecular Dynamic Simulations

BioRxiv : the Preprint Server for Biology
Nabil AbidG. Chillemi

Abstract

Rotavirus group A remains a major cause of diarrhea in infants and young children worldwide. The permanently emergence of new genotypes puts the potential effectiveness of vaccines under serious question. Thirteen VP1 mutants were analyzed using molecular dynamic simulations and the results were combined with the experimental findings, reported previously. The results revealed structural fluctuations and secondary structure change of VP1 protein that may alter its function during viral replication/transcription. Altogether, the structural analysis of VP1 may boost efforts to develop antivirals, as they might complement the available vaccines.

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Mentioned in this Paper

Computer Software
Spatial Distribution
Yeasts
Genomics
Extraction
Microbial
Analysis
Oxygen
Saccharomyces cerevisiae
Surface

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