PMID: 8586999Oct 1, 1995Paper

Scanning and transmission electron microscopic studies of microvascular pathology in the osmotically impaired blood-brain barrier

Journal of Neurocytology
A S LossinskyH M Wisniewski

Abstract

The present investigation focused on the structural events occurring in endothelial cells lining the lumina of brain microvessels in rats subjected to a single intracarotid injection of hypertonic 1.8 M L (+) arabinose solution with or without intravenous injection of horseradish peroxidase. Blood vessels from cerebral cortex and thalamus were evaluated by transmission and scanning electron microscopy. After short-term exposure (10-12 min) there was widespread flooding of peroxidase into the brain neuropil of the ipsilateral hemisphere. Peroxidase tracer was frequently observed within vesiculo-tubular profiles, and occasionally within widened interendothelial junctional clefts. Partially fragmented, necrotic endothelial cells appeared to be in the process of desquamation. Individual endothelial cells appeared to be shrunken with widened interendothelial spaces. Some healthy endothelial cells appeared to be involved in repair processes, manifested by the extension of thin cellular processes towards the area of vessel injury. Other pathological alterations included a conspicuous increase in the number of endothelial cell microvilli, large crater-like invaginations of the endothelial plasma membranes and muscular blood vessels in ...Continue Reading

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Citations

Jun 8, 2007·Pharmaceutical Research·William M Pardridge
Oct 13, 2007·Pharmaceutical Research·Jamie M BergenSuzie H Pun
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
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May 26, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Intakhab AlamM Akbar
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Jan 3, 2007·Drug Discovery Today·William M Pardridge
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Feb 18, 2010·Medicinal Research Reviews·Christian CeliaMassimo Fresta
Aug 18, 2004·Ultrasound in Medicine & Biology·Nickolai SheikovKullervo Hynynen
Jun 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reham S ElezabyGehanne A Awad
Jan 14, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Beth A ValentineAndrea L Sanchez
Jul 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M Pardridge
Mar 19, 2015·American Journal of Rhinology & Allergy·Marcel Menon Miyake, Benjamin S Bleier
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Oct 31, 2019·Molecular Pharmaceutics·Kavisha R UlapaneTeruna J Siahaan

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