Scanning electrochemical microscopy in neuroscience

Annual Review of Analytical Chemistry
Albert SchulteW Schuhmann

Abstract

This article reviews recent work involving the application of scanning electrochemical microscopy (SECM) to the study of individual cultured living cells, with an emphasis on topographical and functional imaging of neuronal and secretory cells of the nervous and endocrine system. The basic principles of biological SECM and associated negative amperometric-feedback and generator/collector-mode SECM imaging are discussed, and successful use of the methodology for screening soft and fragile membranous objects is outlined. The drawbacks of the constant-height mode of probe movement and the benefits of the constant-distance mode of SECM operation are described. Finally, representative examples of constant-height and constant-distance mode SECM on a variety of live cells are highlighted to demonstrate the current status of single-cell SECM in general and of SECM in neuroscience in particular.

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Citations

Jul 29, 2011·Analytical Chemistry·Xiaonan ShanNongjian Tao
Dec 4, 2012·Sensors·Patrick HappelIrmgard D Dietzel
Apr 26, 2016·Analytical Chemistry·David PerryPatrick R Unwin
Oct 28, 2011·Physical Chemistry Chemical Physics : PCCP·Michael V MirkinYixian Wang
Nov 20, 2013·Nanoscale·Martin HüskeBernhard Wolfrum
Aug 2, 2020·Angewandte Chemie·Lianhuan HanZhong-Qun Tian
Mar 17, 2017·Annual Review of Analytical Chemistry·Liang YuanWei Wang
May 20, 2020·Analytical and Bioanalytical Chemistry·Ran ChenMei Shen
Mar 7, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Felipe ConzueloWolfgang Schuhmann
May 10, 2017·Proceedings. Mathematical, Physical, and Engineering Sciences·Ashley PagePatrick R Unwin
Dec 19, 2012·Journal of the American Chemical Society·Joshua P GuerretteBo Zhang
Jun 15, 2011·Nano Letters·Marcel A G ZevenbergenSerge G Lemay
Jan 27, 2012·Chemical Reviews·Francisco Zaera
May 7, 2013·Analytical Chemistry·Alexey YakushenkoBernhard Wolfrum
Nov 6, 2012·Analytical Chemistry·Stephen M OjaBo Zhang
Oct 25, 2011·Analytical Chemistry·Christopher Batchelor-McAuleyRichard G Compton
Dec 10, 2016·Analytical Chemistry·Alexandra BondarenkoHorst Pick

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Methods Mentioned

BETA
scanning probe microscopy
chips
electrophoresis
Scanning Electrochemical Microscopy
electrochemical microscopy
atomic force microscopy
AFM
optical microscopy
microsensor

Software Mentioned

SNOM
STA
SECM
SICM

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