PMID: 7030454Dec 1, 1981Paper

Scanning electron microscopy of the central nervous system. I. The cerebellum

Brain Research
A B ScheibelI Fried

Abstract

The fine structure of the cerebellar cortex has been studied by means of scanning electron microscopy (SEM). The neuropil is revealed by careful tearing of aldehyde-fixed tissue specimens which are prepared by means of dehydration, critical point freeze-drying, and sputter-coating with gold-palladium. Specimens are subsequently viewed at magnifications of up to X 16,000 with capabilities for extension up to about X 40,000. The technique provides remarkable three-dimensional views of neuropil including cell bodies and dendrites, details of presynaptic and postsynaptic morphology, axonal structure, neuroglia, and the microvasculature. It seems particularly powerful in demonstrating relationships between neuropil elements such as the terminal synaptic array on neuron somata and the arrangements of structures on membrane surfaces.

References

Nov 1, 1974·Journal of Neurocytology·V Chan-PalayS M Billings-Gagliardi
Aug 1, 1974·Journal of Neurocytology·R F Foelix, R Oppenheim
Jul 1, 1972·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·K Otsuki
Feb 15, 1974·The Journal of Comparative Neurology·M W Cloyd, F N Low
Jan 1, 1969·Journal of Microscopy·A Boyde, C Wood
Jan 1, 1966·Experimental Brain Research·J C EcclesK Sasaki
Jan 1, 1980·Cell and Tissue Research·O J Castejón, A J Caraballo

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Citations

Oct 12, 2016·Scientific Reports·Ryuta MizutaniKentaro Uesugi
Mar 10, 1984·The Journal of Comparative Neurology·F R RobinsonM Glickstein

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