Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma.

Indian Journal of Ophthalmology
R SihotaTapas C Nag

Abstract

To study ultrastructural changes of the trabecular meshwork in acute and chronic primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG) eyes by scanning electron microscopy. Twenty-one trabecular meshwork surgical specimens from consecutive glaucomatous eyes after a trabeculectomy and five postmortem corneoscleral specimens were fixed immediately in Karnovsky solution. The tissues were washed in 0.1 M phosphate buffer saline, post-fixed in 1% osmium tetraoxide, dehydrated in acetone series (30-100%), dried and mounted. Normal trabecular tissue showed well-defined, thin, cylindrical uveal trabecular beams with many large spaces, overlying flatter corneoscleral beams and numerous smaller spaces. In acute PACG eyes, the trabecular meshwork showed grossly swollen, irregular trabecular endothelial cells with intercellular and occasional basal separation with few spaces. Numerous activated macrophages, leucocytes and amorphous debris were present. Chronic PACG eyes had a few, thickened posterior uveal trabecular beams visible. A homogenous deposit covered the anterior uveal trabeculae and spaces. Converging, fan-shaped trabecular beam configuration corresponded to gonioscopic areas of peripheral anterior synechi...Continue Reading

References

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Citations

Feb 18, 2016·Asia-Pacific Journal of Ophthalmology·Jimmy LaiJennifer W H Shum
May 17, 2014·Current Eye Research·Michaël J A GirardNicholas G Strouthidis
Mar 1, 2017·Clinical & Experimental Ophthalmology·Alexis Galeno MatosJayter Silva Paula
Apr 28, 2017·PloS One·María T García-AntónJosé M Ramírez
Jun 18, 2017·Ocular Immunology and Inflammation·Taiki KokubunToru Nakazawa
Mar 21, 2018·Current Eye Research·Jing WangXun Xu
Nov 25, 2018·International Ophthalmology·Tarannum MansooriNagalla Balakrishna
Jun 21, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ramanjit SihotaTanuj Dada

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Methods Mentioned

BETA
scanning electron microscopy
dissection

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