PMID: 8985774Oct 1, 1996Paper

Scanning electron microscopy shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice

International Journal of Andrology
T ShonoS Ramm-Anderson

Abstract

The morphological relationship between transabdominal testicular descent and the 'swelling reaction' of the gubernaculum was investigated in oestrogen-treated fetal mice by using scanning electron microscopy (scanning EM). In addition, flutamide was also administered to pregnant mice to determine whether androgens cause gubernacular growth and transabdominal testicular descent in offspring. In oestrogen-treated fetal mice, scanning EM showed that both the gubernacular 'swelling reaction' and transabdominal testicular descent were inhibited, in addition to inhibition of Müllerian duct regression. The gubernaculum showed a flat, thin bulb (widest diameter 0.25 +/- 0.04 mm) and an elongated cord (1.28 +/- 0.41 mm) after oestrogen treatment in utero, which was significantly different in appearance from that in normal control mice (width 0.44 mm +/- 0.06 mm, p < 0.001; length 0.27 +/- 0.19 mm, p < 0.0001). However, flutamide-treated mice showed much more normal gubernacular enlargement and transabdominal testicular descent. The width of the gubernacular bulb after flutamide exposure was 0.44 +/- 0.05 mm, which was comparable to that in control animals; the length of the intra-abdominal gubernaculum (0.44 +/- 0.15 mm) was slightly lo...Continue Reading

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Citations

Jun 10, 2005·Biology of Reproduction·Christophe StaubBernard Jégou
Dec 1, 1994·International Journal of Andrology·J M Hutson
Sep 24, 2004·International Journal of Andrology·Ibrahim M Adham, Alexander I Agoulnik
Aug 6, 2000·Developmental Biology·S NefL F Parada
Dec 1, 2011·Molecular and Cellular Endocrinology·Helena E Virtanen, Annika Adamsson
Jul 3, 1999·Nature Genetics·S Nef, L F Parada
Mar 16, 2011·Nature Reviews. Urology·Katrine BayNiels E Skakkebæk
Mar 24, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·R P Amann, D N R Veeramachaneni

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