Scanning force microscopy of the interaction events between a single molecule of heavy meromyosin and actin

Biochemical and Biophysical Research Communications
H NakajimaToshio Ando

Abstract

How close an approach is necessary for two interactive protein molecules to recognize each other before association? How strong a force field is exerted between two proteins at the recognition distance? How extensive are the association interfaces? How strong a force is necessary to pull the associated proteins apart? By means of atomic force microscopy at a truly single molecule level, these fundamental and intriguing questions were answered with the muscle proteins actin and myosin.

Citations

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