Scanning the HIV genome for CD4+ T cell epitopes restricted to HLA-DP4, the most prevalent HLA class II molecule

The Journal of Immunology : Official Journal of the American Association of Immunologists
William M CohenBernard Maillère

Abstract

HLA-DP4 alleles are carried by 75% of individuals and are the most frequent HLA II alleles worldwide. Because we have recently characterized the peptide-binding specificity of HLA-DP4 molecules, we developed a peptide-binding prediction method to identify HLA-DP4-restricted peptides in multiple Ags. CD4(+) T cell response plays a key role in the immune control of HIV infection, but few HIV-specific T cell epitopes with multi-individual specificity have been identified. They are mostly restricted to HLA-DR molecules, which are very polymorphic molecules. We therefore looked for HLA-DP4-restricted CD4(+) T cell epitopes in the whole genome of HIV. Twenty-one peptides were selected from the HXB2 HIV genome based on the prediction of binding to HLA-DP4 molecules. They were submitted to HLA-DP4-binding assays. Seventeen peptides bound to the HLA-DP401 molecule, whereas 15 peptides bound to HLA-DP402. Six peptides bound very tightly to HLA-DP401 and were investigated for their capacity to induce specific CD4(+) T cell lines in vitro using dendritic cells and CD4(+) T cells collected from eight seronegative HLA-DP4(+) donors. Four peptides from env and reverse transcriptase proteins induced in vitro-specific T cell lines restricted to...Continue Reading

References

Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Jan 1, 1994·Immunogenetics·H WrightJ Redmond
Mar 2, 1999·The Journal of Experimental Medicine·P ChauxP van der Bruggen
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·H M ZarourW J Storkus
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C TexierB Maillère
Feb 22, 2001·The Journal of Clinical Investigation·U MalhotraM J McElrath
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·G ZengR F Wang
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A C McNeilM Connors
Aug 29, 2002·Clinical and Experimental Immunology·V PancréC Auriault
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florence A CastelliBernard Maillère
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·G AlterN F Bernard
Dec 17, 2003·The Journal of Experimental Medicine·Souheil-Antoine YounesRafick-Pierre Sekaly
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erwin S SchultzGerold Schuler
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent E PalmerCara C Wilson
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed ElrefaeiHuyen Cao
Aug 11, 2004·Virology·Patricia M A de GraaffGrada M van Bleek
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shabnam TangriAlessandro Sette

❮ Previous
Next ❯

Citations

May 12, 2007·European Journal of Immunology·Florence A CastelliBernard Maillere
Feb 16, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Daniela Santoro RosaEdecio Cunha-Neto
Sep 22, 2006·Cancer Immunology, Immunotherapy : CII·Xiao-Fei WangBernard Maillère
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiao-Fei WangBernard Maillère
Feb 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John SidneyAlessandro Sette
Sep 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John SidneyAlessandro Sette
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carla OseroffAlessandro Sette
Jun 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Makito TanakaNaoto Hirano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.