PMID: 7547789Aug 1, 1995Paper

Scar tissue orientation in unsutured and sutured corneal wound healing

The British Journal of Ophthalmology
G R MellesN SundarRaj

Abstract

This study aimed to evaluate stromal wound healing morphology in short term unsutured compared with sutured corneal wounds, to define regional variation in healing within radial keratotomy wounds. Stromal scar tissue orientation (fibroblast and collagen fibre orientation) was analysed in unsutured and adjacent sutured keratotomy wounds in monkeys, 2 to 9 weeks after surgery, using light and transmission electron microscopy. At 2 to 4 weeks, scar tissue orientation was transverse to the wound edge in unsutured wounds, but sagittal in sutured wounds. At 5 to 9 weeks, a reorientation of scar tissue sagittal to the wound was seen in the unsutured wounds, proceeding from the posterior to anterior wound regions. In sutured wounds, a scar tissue reorientation transverse to the wound was seen, proceeding from the anterior wound region in a posterior direction. Within the same cornea, sutured and unsutured wounds showed opposite patterns of healing. Sutured wounds initially healed more slowly, but obtained pseudolamellar continuity over time. In contrast, healing of unsutured wounds was characterised by an early approximation towards lamellar repair that was followed by an ineffective reorganisation of the scar. This latter pattern of h...Continue Reading

References

Oct 1, 1978·Journal of Ultrastructure Research·C CintronD J Cannon
Oct 1, 1990·Archives of Ophthalmology·G R Melles, P S Binder
Oct 1, 1983·The Journal of Investigative Dermatology·W T McGaw, A R Ten Cate
Jan 1, 1983·Journal of Mathematical Biology·J D MurrayA K Harris
Aug 1, 1981·American Journal of Ophthalmology·J V JesterR E Smith
Aug 1, 1980·Experimental Eye Research·S A Fowler

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Citations

Jan 10, 1998·Journal of Cataract and Refractive Surgery·K M GoinsJ T Ernest
Nov 3, 2005·Developmental Biology·Peter Y LwigaleMarianne Bronner-Fraser
Jun 1, 2017·Acta Biomaterialia·Vijay Krishna RaghunathanChristopher J Murphy
May 23, 2008·American Journal of Physiology. Cell Physiology·Jia Yin, Fu-Shin X Yu
Jul 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jade MontgomeryRobert G Gourdie

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