Abstract
Scavenger receptor class A member 5 (SCARA5) is a candidate anti-oncogene in several malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role in breast cancer cell growth and metastasis remain to be determined. Here, we investigated the biological functions of SCARA5 in the progression and metastasis of breast cancer and explored the underlying mechanisms. A total of 65 breast cancer patients and three cell lines (ZR-75-30, MCF-7, and MDA-MB-231) were analyzed in the study. RT-qPCR, western blotting, and immunohistochemistry were used to detect mRNA and protein expression, and lymphatic vessel density (LVD) and microvessel density (MVD). MTT, colony formation, TUNEL assays, invasion assays and Transwell assays, and flow cytometric analyses were used to evaluate the effect of SCARA5 on breast cancer cells. SCARA5 was significantly downregulated in breast cancer tissues and cells and significantly correlated with tumor size, histological grade, lymph node metastasis, pTNM stage, VEGF-A, VEGF-C, LVD, and MVD. SCARA5 overexpression significantly suppressed cell proliferation, colony formation, invasion, and migration, and induced G0/G1 arrest and apoptosis of ZR-75-30 cells. SCARA5 decreased the phos...Continue Reading
References
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Aug 1, 1993·Genes & Development·D E QuelleC J Sherr
Sep 18, 1997·Journal of the National Cancer Institute·A F Chambers, L M Matrisian
Aug 15, 1997·The Biochemical Journal·G M Cohen
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Nov 13, 1998·The Journal of Biological Chemistry·A HwangR J Muschel
Mar 17, 2001·Microbes and Infection·L Peiser, S Gordon
Jul 27, 2001·The Journal of Surgical Research·G D KymionisS Michalas
Jan 23, 2002·Cell Death and Differentiation·Guy S Salvesen
Apr 18, 2002·Oncogene·Guilian NiuHua Yu
Jan 25, 2003·Oncogene·Daoyan WeiKeping Xie
Jul 23, 2003·The Journal of Biological Chemistry·Yoko YahataKoji Hashimoto
Nov 13, 2003·Seminars in Oncology·Rita Nahta, Francisco J Esteva
Apr 3, 2004·Trends in Molecular Medicine·Mark E Ewen, Justin Lamb
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Weida GongSuyun Huang
May 14, 2005·CA: a Cancer Journal for Clinicians·Irene M GhobrialAlex A Adjei
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Mar 17, 2006·Cancer Research·Tong-xin XieSuyun Huang
Jan 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carolyn C GotayFabio Efficace
Jul 16, 2008·Seminars in Cell & Developmental Biology·Bernd GronerCorina Borghouts
Jan 22, 2009·Developmental Cell·Jau Yi LiJonathan Barasch
Jun 10, 2009·Journal of Medical Genetics·S GhavamiM Los
Dec 30, 2009·The Journal of Clinical Investigation·Jian HuangZe-Guang Han
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Everardo D SaadMarc Buyse
Sep 18, 2010·Breast Care·Paola Parrella
May 31, 2012·Cancer Science·Nv YanHongxin Deng
Nov 28, 2012·Life Sciences·Fausto Gueths GomesSandra Beatriz Chaves Tarquinio
Nov 28, 2012·BMC Evolutionary Biology·Fiona J WhelanDawn M E Bowdish
Feb 21, 2013·PloS One·Di HuIichiro Shimomura
Feb 25, 2014·Nature Reviews. Cancer·Steven A StackerMarc G Achen
May 3, 2014·Seminars in Oncology·Kriti MittalBrian Rini
Jul 9, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jing HuYukuan Feng
Apr 18, 2015·BMC Cancer·Hongxia ChenChangyan Chen
May 8, 2015·Oncotarget·Pei ZhangYuping Sun
Feb 6, 2016·Molecular Medicine Reports·Xinzhu WenChunjiao Dong
Citations
May 24, 2018·International Journal of Molecular Sciences·Liangfu ZhouPeng Shang
Feb 21, 2018·Proteomics. Clinical Applications·Ying LiuLai-Ping Zhong
Mar 30, 2019·Reproduction, Fertility, and Development·A Vitorino CarvalhoO Sandra
Jun 27, 2019·Journal of Cellular Physiology·Su ZhangZhi-Ping Wang
Aug 21, 2020·DNA and Cell Biology·Feiran WangZhixian He
Jun 27, 2019·BMC Bioinformatics·Marta B LopesSusana Vinga
Apr 25, 2020·Frontiers in Oncology·Rikki A M BrownPeter J Leedman
May 26, 2020·BMC Cancer·Guangzhi Wu, Minglei Zhang
Feb 6, 2020·Chonnam Medical Journal·Sunhyo RyuPeter I Song
Dec 12, 2018·Frontiers in Oncology·Christa Pfeifhofer-ObermairManfred Nairz
Dec 1, 2017·Digestive Diseases and Sciences·Hongliang LiuWei Xu
Dec 9, 2020·Cells·Myriam Y HsuPaolo E Porporato
Nov 11, 2020·Animals : an Open Access Journal From MDPI·Liyuan LiuYaling Gu
May 21, 2021·Life Sciences·Xin-Sheng LuShi-Min Liu
Jun 7, 2021·Trends in Pharmacological Sciences·Karolin RoemhildTwan Lammers
Jun 22, 2021·Frontiers in Oncology·Qi PengTingxiu Xiang
Aug 22, 2021·Genes & Genomics·Yi LiYeqing Xu