Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability

ACS Omega
Bo PengKam W Leong

Abstract

Burn, trauma, and various medical conditions including bacterial infection, diabetes complication, and surgery could lead to an acute cutaneous wound and scar formation. Application of tissue glues instead of sutures could minimize the additional trauma and scar formation. Despite the countless efforts devoted to the development of high-strength tissue glues, little attention has been paid to their influence on the scar formation. Here, we report the development of a new tissue glue with excellent biocompatibility and tunable degradability for scarless wound closure. A series of catechol-containing poly(amidoamine) (CPAA) polymers were synthesized via the one-step Michael addition of dopamine and bisacrylamide. The tertiary amino group in the polymer backbone was used to introduce a zwitterionic sulfobetaine group by one-step ring-opening polymerization. The introduction of the zwitterionic sulfobetaine group could easily tune the hydrophilicity and the degradability of CPAA without influencing the density of the catechol group in the polymer. Lap-shear tests on the porcine skin demonstrated a high adhesion strength of 7 kPa at 1 h, rising to 24 kPa by 12 h. Addition of silica nanoparticles could further enhance the adhesion st...Continue Reading

References

Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·E RanucciR Duncan
Jan 1, 1983·Annals of the New York Academy of Sciences·J G Harter
Nov 12, 1998·Plastic and Reconstructive Surgery·D M ToriumiA Bagal
Sep 10, 2002·Biomacromolecules·Bruce P LeePhillip B Messersmith
Oct 1, 1958·Plastic and Reconstructive Surgery and the Transplantation Bulletin·C E HORTONR A LOEFFLER
Nov 2, 2006·Aesthetic Plastic Surgery·Alessandro SilvestriCarlo D'Aniello
Jul 20, 2007·Nature·Haeshin LeePhillip B Messersmith
Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Jun 3, 2008·Advanced Drug Delivery Reviews·Igor I SlowingVictor S-Y Lin
Oct 9, 2009·Biomaterials·Carrie E BrubakerPhillip B Messersmith
Jul 9, 2010·Journal of the American College of Surgeons·Andre ChowSanjay Purkayastha
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hongbo ZengJ Herbert Waite
Jan 5, 2011·Acta Biomaterialia·Qian YuHong Chen
Jun 15, 2011·Clinical Lung Cancer·Ravi K BobbaMichael C Perry
Nov 8, 2011·Annual Review of Materials Research·Bruce P LeeJ H Waite
Nov 9, 2011·Biomacromolecules·Carrie E Brubaker, Phillip B Messersmith
Dec 14, 2011·Nature Medicine·Victor W WongGeoffrey C Gurtner
Mar 1, 2012·Biomaterials·Dominic E FullenkampPhillip B Messersmith
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
May 16, 2012·Journal of the American Chemical Society·Cristina R Matos-PérezJonathan J Wilker
Nov 28, 2012·Advanced Healthcare Materials·Devin G BarrettPhillip B Messersmith
Jan 8, 2013·Macromolecules·Cristina R Matos-Pérez, Jonathan J Wilker
May 15, 2013·ACS Applied Materials & Interfaces·Courtney L JenkinsJonathan J Wilker
Jan 28, 2014·ACS Applied Materials & Interfaces·Xiaomeng LiGuolin Wu
Mar 22, 2014·Biomacromolecules·Bum Jin KimHyung Joon Cha
Jun 25, 2014·Nature Communications·Michael C GianoJoel P Schneider
Jul 16, 2014·ACS Applied Materials & Interfaces·Peiyu SunXinling Wang
Sep 19, 2014·Chemical Society Reviews·Juan YangMarleen Kamperman
Dec 3, 2014·Journal of Vascular and Interventional Radiology : JVIR·Brandt C WibleKenneth H Cho
Feb 28, 2015·Advanced Healthcare Materials·Mohammad NorouziMasoud Soleimani
Aug 22, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M G Berry, Jan J Stanek
Oct 20, 2015·Nature Communications·B Kollbe AhnJ Herbert Waite
Jan 5, 2016·Advanced Healthcare Materials·Samuel J FrostAntonio Lauto
Aug 16, 2016·Advanced Materials·Seonki HongRalph Weissleder
Nov 15, 2016·Advanced Functional Materials·Wei WeiJ Herbert Waite
Nov 26, 2016·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·John Biddlestone, David McGill
Oct 12, 2015·ACS Biomaterials Science & Engineering·Yinfeng ShiSeema Agarwal

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Citations

Apr 23, 2020·Journal of Biomedical Materials Research. Part a·Seckin AltuncuDuygu Avci
Jan 12, 2021·Nano Today·Ayça Bal-OzturkShabir Hassan
Jun 25, 2021·ACS Biomaterials Science & Engineering·Yifan ZhangXiaoya Liu
Jul 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yifan ZhangXiaoya Liu
Sep 4, 2021·Chemical Society Reviews·Anika Benozir AshaRavin Narain
Sep 23, 2021·Biomaterials Science·Natan Roberto BarrosHan-Jun Kim

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