PMID: 9426685Jan 14, 1998Paper

Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cells

International Journal of Cancer. Journal International Du Cancer
K LamszusE M Rosen

Abstract

Malignant gliomas are characterized by rapid growth, infiltration of normal brain tissue, and high levels of tumor-associated angiogenesis. The genetic and local environmental tissue factors responsible for the malignant progression from low to high grade gliomas and the highly malignant behavior of glioblastomas are not well understood. In a study of 77 human brain tissue extracts, high grade (III-IV) tumors had significantly greater scatter factor (SF) content than did low grade tumors or non-neoplastic tissue. To investigate the potential significance of SF accumulation in gliomas, we measured the effects of SF on DNA synthesis and motility of cultured human glioma cell lines. SF stimulated DNA synthesis in 7/10 glioma cell lines and in 3/3 neuromicrovascular endothelial cell (NMVEC) lines, consistent with our previous report that SF stimulated cell proliferation of a few human glioma cell lines. SF markedly stimulated the chemotactic migration of 10/10 glioma cell lines as well as 3/3 NMVEC lines. In addition, SF stimulated the 2-dimensional migration of glioma cells on culture surfaces coated with specific extracellular matrix molecules (collagen i.v., laminin, and fibronection). As expected based on these biologic respons...Continue Reading

References

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E GherardiR Furlong
Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E M RosenD W Vinter
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D S GrantE M Rosen
Dec 1, 1994·The Journal of Cell Biology·E M RosenI D Goldberg
Dec 2, 1993·International Journal of Cancer. Journal International Du Cancer·L AnkerM Westphal
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·P H PedersenO D Laerum
Apr 10, 1996·International Journal of Cancer. Journal International Du Cancer·H OkadaM Hagiwara
May 29, 1996·International Journal of Cancer. Journal International Du Cancer·T MoriyamaM Koono
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·E M RosenI D Goldberg
Jun 27, 1997·Biochemical and Biophysical Research Communications·J LaterraP Johnston

❮ Previous
Next ❯

Citations

Oct 11, 2005·Neuro-oncology·Roger Abounader, John Laterra
Oct 11, 2005·Neuro-oncology·Oliver HeeseKatrin Lamszus
Jul 9, 2009·Molecular Cancer Therapeutics·Bachchu LalJohn Laterra
Sep 10, 2009·Annual Review of Pathology·Candece L GladsonWei Michael Liu
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·M E Berens, A Giese
Nov 1, 2008·Cancer·Doo-Sik KongDo-Hyun Nam
Jan 16, 2008·Journal of Cellular and Molecular Medicine·R A TownerF Lupu
Aug 19, 2009·Journal of Cellular Physiology·Marcin Teodorczyk, Ana Martin-Villalba
May 30, 2006·Biochemical and Biophysical Research Communications·Shuli Xia, John Laterra
Oct 22, 2008·Expert Review of Neurotherapeutics·Sajani S Lakka, Jasti S Rao
Oct 29, 2013·Journal of Signal Transduction·Joseph C LoftusDaniel L Riggs
Sep 5, 2002·Journal of Neuroscience Research·Henglin Yan, Scott A Rivkees
Feb 7, 2017·PloS One·Wanho LeeYangjin Kim
Mar 31, 2011·International Journal of Cancer. Journal International Du Cancer·Shilpi AroraGlen J Weiss
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roger AbounaderJohn Laterra
Mar 21, 2007·Expert Opinion on Investigational Drugs·David E Gerber, John Laterra
Nov 2, 2016·Frontiers in Molecular Neuroscience·Firas H KobeissyJialing Liu
Mar 20, 2018·Oncogene·Leslie DuplaquetDavid Tulasne
Dec 25, 2003·Journal of Neuropathology and Experimental Neurology·Ulrike UlbrichtKatrin Lamszus
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Yuan RongDaniel J Brat
Dec 2, 2014·Neurosurgical Focus·Ahmed J AwadRoger Abounader
Jul 2, 2020·AIMS Neuroscience·Zygmunt SiedleckiMaciej Śniegocki
Jan 18, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marie E BecknerIan F Pollack
Nov 1, 2011·Journal of Neuro-oncology·Shu-Shong HsuLi-Feng Liu
Dec 31, 1998·Current Opinion in Neurology·J L Darling, T J Warr
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K LamszusE M Rosen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.