Scatter factors and invasive growth

Seminars in Cancer Biology
P M Comoglio, C Boccaccio

Abstract

Scatter factors are unequivocal signals governing a genetic program that includes cell detachment, repulsion, protection from apoptosis, invasiveness of extracellular matrices and proliferation. This pleiomorphic response is defined as 'invasive growth'. Under physiological conditions, it leads to morphogenic cell movements through the matrix, and--primarily--to ordered building of epithelial tubules. Dysfunctions in invasive growth cause enhanced proliferation, uncontrolled migration into surrounding tissues, and failure to differentiate, events that foster tumour growth and invasiveness. Scatter factors act through tyrosine kinase receptors that belong to the Met oncogene family. Here we discuss how alterations of these receptors or of their signal transduction pathways are responsible for cancer onset and progression towards metastasis.

References

May 1, 1991·The Journal of Experimental Medicine·A SkeelE J Leonard
Apr 1, 1991·Molecular and Cellular Biology·L NaldiniP M Comoglio
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N R SomanG N Wogan
Jun 20, 1986·Cell·M ParkG F Vande Woude
May 11, 1989·Nature·S GiordanoP M Comoglio
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NakamuraA Ichihara
Dec 1, 1994·Protein Science : a Publication of the Protein Society·L E DonateT L Blundell
Sep 1, 1994·International Journal of Cancer. Journal International Du Cancer·M F Di RenzoP M Comoglio
Apr 1, 1994·The Journal of Cell Biology·T CrepaldiP M Comoglio
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KawaidaT Nakamura
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·E MaestriniP M Comoglio
Jun 1, 1996·The Journal of Cell Biology·M SachsW Birchmeier
Jun 14, 1996·The Journal of Biological Chemistry·C PonzettoP Comoglio
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M GranoP M Comoglio
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·E Santoni-RugiuS S Thorgeirsson
Apr 1, 1996·Trends in Genetics : TIG·B PasiniG Romeo
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·H TakayamaG Merlino
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Jul 4, 1997·The Journal of Biological Chemistry·M H WangE J Leonard
Jun 1, 1997·Cytokine & Growth Factor Reviews·L Tamagnone, P M Comoglio
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M JeffersG F Vande Woude

❮ Previous
Next ❯

Citations

Jun 16, 2009·Clinical & Experimental Metastasis·Kyung Hee Lee, Jae-Ryong Kim
Oct 2, 2004·Nature Cell Biology·Karni Schlessinger, Alan Hall
Oct 6, 2007·Cell Death and Differentiation·D Tulasne, B Foveau
Apr 11, 2003·Molecular Biology of the Cell·Dean E HammondMichael J Clague
Apr 3, 2002·The Journal of Clinical Investigation·Paolo M Comoglio, Livio Trusolino
Nov 7, 2002·Biological & Pharmaceutical Bulletin·Shingo NiimiTakao Hayakawa
Jul 8, 2011·Experimental & Molecular Medicine·Kyung Hee LeeJae-Ryong Kim
May 31, 2013·Journal of Biomedical Research·Wenze SunJie Cui
Apr 23, 2013·International Journal of Hepatology·Neeta K Venepalli, Laura Goff
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Benedetta PeruzziDonald P Bottaro
Dec 24, 2014·Expert Opinion on Therapeutic Targets·Anna LiYi-Long Wu
Apr 26, 2012·Expert Opinion on Therapeutic Targets·Fabiola CecchiDonald P Bottaro
Apr 30, 2003·The Journal of Cell Biology·Yuri ChurinMichael Naumann
Jan 29, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Heounjeong GoDoo Hyun Chung
Aug 24, 2013·The Journal of Nutritional Biochemistry·Holly L NicastroLeonard F Bjeldanes
May 3, 2014·Pharmacology & Therapeutics·Lluís NisaMichaela Medová
Jan 23, 2010·Bioorganic & Medicinal Chemistry Letters·Hiroki NishiiHiroshi Koyano
Dec 23, 2008·Cancer Letters·Christine M Stellrecht, Varsha Gandhi
Aug 2, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nicole A CiprianiRavi Salgia
Apr 25, 2008·Bioorganic & Medicinal Chemistry Letters·Stephen ClaridgeArkadii Vaisburg
May 16, 2014·Scientific Reports·Young Mi OhKyung-Ah Kim
Dec 16, 2003·American Journal of Reproductive Immunology : AJRI·Florian M CorvinusUdo R Markert
Oct 16, 2010·Human Mutation·Giulia M StellaPaolo M Comoglio
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Hidenori TanakaKazuto Hirata
Dec 21, 2004·Critical Reviews in Oncology/hematology·Wen G JiangToshikazu Nakamura
Jul 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael D OberstChen-Yong Lin
Jun 9, 2017·The Korean Journal of Thoracic and Cardiovascular Surgery·Sung Ho ChoKang Won Jang
Oct 7, 2003·Oncogene·Thomas Bogenrieder, Meenhard Herlyn
Jan 10, 2002·Nature Cell Biology·Rüdiger Klein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis