Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1

The FEBS Journal
Mengying XieDaming Zuo

Abstract

The battle between hepatitis B virus (HBV) infection and the host immune defense determines the outcome of the disease. Scavenger receptor A (SRA) is a phagocytic pattern recognition receptor involved in various cellular processes, including lipid metabolism, recognition, and clearance of pathogens or modified self-molecules. Emerging evidence pointed out that SRA might act as an immunomodulator that contributes to innate immune defense against invading pathogens. Herein, we examined the role of SRA in the initiation of type I interferon (IFN) response to HBV infection and the virus clearance. Our results showed that SRA-deficient (SRA-/- ) mice were resistant to HBV infection developed by hydrodynamic injection of HBV replicon plasmid. We found lower levels of HBV DNA and viral protein expression in SRA-/- mice, which was associated with enhanced type I IFN production, compared with wild-type controls. Besides, we performed gain and loss of function experiments and determined that SRA inhibits innate antiviral immune responses to HBV. SRA could interact directly with tumor necrosis factor receptor-associated factor 3 (TRAF3) and inhibit its K63-linked ubiquitination. Moreover, we provided evidence that SRA negatively regulates...Continue Reading

References

Jan 16, 2002·Current Opinion in Immunology·Leanne PeiserSiamon Gordon
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Apr 2, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maurizia Rossana BrunettoPatrick Marcellin
Dec 10, 2009·The Journal of Biological Chemistry·Shu LiHong-Bing Shu
Jun 11, 2011·Nature Reviews. Immunology·Hans HäckerMichael Karin
Mar 7, 2012·Microbiology and Molecular Biology Reviews : MMBR·Jonathan Maelfait, Rudi Beyaert
Jul 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daming ZuoXiang-Yang Wang
Jun 14, 2013·Journal of Molecular Signaling·Ping Xie
Aug 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hsin-Lin Lu, Fang Liao
Feb 11, 2014·Virology Journal·Aurelia Busca, Ashok Kumar
Jun 19, 2015·Immunological Reviews·Wai W LinGail A Bishop
Jul 3, 2015·Cold Spring Harbor Perspectives in Medicine·Anthony TanAntonio Bertoletti
Sep 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Srinivas NellimarlaKaren L Mossman
Feb 15, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guofeng ChenGeorge Lau
Apr 30, 2017·Frontiers in Immunology·Praneet SandhuJianxun Song
Jun 20, 2017·Journal of Molecular Biology·Ben A Bailey-ElkinBrian L Mark
Jun 16, 2018·The Journal of Biological Chemistry·Di XinQinmiao Sun
Jun 20, 2018·Biochemical and Biophysical Research Communications·Xiaojuan ChenZhongbin Chen
Aug 17, 2018·PLoS Pathogens·Guoxin NiBlossom Damania

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Citations

Feb 5, 2021·Frontiers in Cell and Developmental Biology·Yihao LiaoNing Jiang
Nov 24, 2020·Frontiers in Cell and Developmental Biology·Wei ZhouQifa Ye
Feb 21, 2021·Ageing Research Reviews·Qiong ZhuLingqiang Zhang
May 18, 2021·Frontiers in Immunology·Raphaël JamiStéphane Biacchesi
Jun 30, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ziwen ZhouWuhan Xiao

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