Scavenger receptor b2 as a receptor for hand, foot, and mouth disease and severe neurological diseases.

Frontiers in Microbiology
Seiya YamayoshiSatoshi Koike

Abstract

Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD). Infection with EV71 is occasionally associated with severe neurological diseases such as acute encephalitis, acute flaccid paralysis, and cardiopulmonary failure. Because cellular receptors for viruses play an important role in cell, tissue, and species tropism, it is important to identify and characterize the receptor molecule. Recently, cellular receptors and host factors that stimulate EV71 infection have been identified. Several lines of evidence suggest that scavenger receptor class B, member 2 (SCARB2) plays critical roles in efficient EV71 infection and the development of disease in humans. In this review, we will summarize the findings of recent studies on EV71 infection and on the roles of SCARB2.

Citations

Feb 8, 2013·Traffic·Michael SchwakePaul Saftig
Jul 30, 2015·Traffic·Judith BlanzMichael Schwake
Nov 17, 2016·Scientific Reports·Issac Horng Khit TooSylvie Alonso
May 27, 2015·Cells·Izma Abdul ZaniSreenivasan Ponnambalam
Jan 10, 2018·The Tohoku Journal of Experimental Medicine·Masashi KoideEiji Itoi
Mar 16, 2016·BMC Research Notes·Carlos Omaña-CepedaJosé López-López
Jan 12, 2021·Iranian Journal of Science and Technology. Transaction A, Science·Hai-Vy Vo-NguyenHieu Tran-Van

❮ Previous
Next ❯

Methods Mentioned

BETA
Infection
electron microscopy
transgenic

Related Concepts

Related Feeds

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.

Related Papers

Frontiers in Microbiology
Yorihiro Nishimura, Hiroyuki Shimizu
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
C C LiuI J Su
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
M J DoddP Larson
Archives of Internal Medicine
P KansalN Woodhouse
© 2022 Meta ULC. All rights reserved