Scavenger receptor class B member 1 protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis

Hepatic Medicine : Evidence and Research
Anthony P Kent, Ioannis M Stylianou

Abstract

Scavenger receptor class B member 1 (SR-BI, also known as SCARB1) is the primary receptor for the selective uptake of cholesterol from high-density lipoprotein (HDL). SR-BI is present in several key tissues; however, its presence and function in the liver is deemed the most relevant for protection against atherosclerosis. Cholesterol is transferred from HDL via SR-BI to the liver, which ultimately results in the excretion of cholesterol via bile and feces in what is known as the reverse cholesterol transport pathway. Much of our knowledge of SR-BI hepatic function and regulation is derived from mouse models and in vitro characterization. Multiple independent regulatory mechanisms of SR-BI have been discovered that operate at the transcriptional and post-transcriptional levels. In this review we summarize the critical discoveries relating to hepatic SR-BI cholesterol metabolism, atherosclerosis, and regulation of SR-BI, as well as alternative functions that may indirectly affect atherosclerosis.

Citations

Jun 1, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Antonino PicataggiIoannis M Stylianou
May 24, 2014·Metabolism: Clinical and Experimental·Wen-Jun ShenSalman Azhar
Jul 26, 2014·Histochemistry and Cell Biology·Stefanie FruhwürthHerbert Stangl

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Methods Mentioned

BETA
glycosylation
acylation
transgenic
two-hybrid

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