PMID: 8608170Mar 1, 1996Paper

Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion

Biochimica Et Biophysica Acta
B ZhaoW Xin

Abstract

The scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 = 7 x 10 (-5) mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2/5 x 10(-4) mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase.

References

Apr 30, 1992·Biochemical and Biophysical Research Communications·H KosakaT Shiga
Nov 1, 1992·Chemical Research in Toxicology·W H KoppenolJ S Beckman
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Jan 1, 1990·Free Radical Research Communications·U WestenbergerO Trentz
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J L ZweierM L Weisfeldt
Aug 28, 1981·Biochimica Et Biophysica Acta·S R LouroG Bemski
Sep 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y HenryA Guissani

❮ Previous
Next ❯

Citations

Sep 29, 2011·Journal of Physiology and Biochemistry·Przemysław SosnowskiRafał Jastak
Aug 1, 1996·Current Opinion in Structural Biology·K E SandersS Sligar
Aug 6, 1998·Respirology : Official Journal of the Asian Pacific Society of Respirology·H P LiX M Xia
Nov 26, 2010·Journal of Clinical Biochemistry and Nutrition·Zhang JunjingZhao Baolu
Oct 19, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Min SongHong-Yuan Chen
Mar 3, 2005·Journal of Ethnopharmacology·Xin-Jian WangJian-Xing Xu
Jun 2, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jingwei TianFu Liu
Oct 24, 2008·Phytopathology·Yang Cang XuBao Lu Zhao
Jun 5, 2004·Cardiovascular Drug Reviews·De-Jian JiangYuan-Jian Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.