PMID: 8583360Aug 1, 1995Paper

Scavenging of free-radicals and inhibition of lipid peroxidation by 3-phenylsydnone

The Journal of Pharmacy and Pharmacology
R S Narla, M N Rao

Abstract

The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyribose mediated by hydroxyl radicals, although, to a lesser extent than trolox, a water soluble analogue of vitamin E. Many antioxidants possess pro-oxidant properties due to their ability to reduce ferric ions; however, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homogenates.

References

Jan 1, 1990·Free Radical Research Communications·B Halliwell
Dec 1, 1994·The Journal of Pharmacy and Pharmacology· Sreejayan, M N Rao

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Citations

Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H Jing, D D Kitts
Sep 19, 1998·Journal of Pharmacological and Toxicological Methods·J K CallawayB Jarrott
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·V P VeerapurM K Unnikrishnan
Aug 22, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K R PrabhakarM K Unnikrishnan
Apr 2, 2013·Biochimie·Dimitra Hadjipavlou-LitinaDionissios Papaioannou
Nov 23, 2006·Chemico-biological Interactions·K R PrabhakarM K Unnikrishnan

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