Scavenging of reactive oxygen species by Eriobotrya japonica seed extract

Biological & Pharmaceutical Bulletin
Junko YokotaYutaka Nishioka

Abstract

We have clarified that Eriobotrya japonica seed extract has strong antioxidative activity, and is effective for the prevention and treatment of various diseases, such as hepatopathy and nephropathy. In this study, to investigate the influences of components of Eriobotrya japonica seed extract on its antioxidative activity, extracts were prepared using various solvents (n-hexane (Hex), ethyl acetate (EtOAc), n-butanol (n-BuOH), methanol (MeOH) and H2O) and the antioxidative activity of the solvent fractions and components was evaluated based on the scavenging of various radicals (DPPH and O2(-)) measured by the ESR method and the inhibition of Fe3+-ADP induced NADPH dependent lipid peroxidation in rat liver microsomes. The radical scavenging activities and inhibitory activities on lipid peroxidation differed among the solvent fractions and components. In the n-BuOH, MeOH and H2O fractions, radical scavenging activity and inhibitory activity on lipid peroxidation were high. In addition, these fractions contained abundant polyphenols, and the radical scavenging activity increased with the polyphenol content. In the low-polar Hex and EtOAc fractions, the radical scavenging activity was low, but the lipid peroxidation inhibition act...Continue Reading

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Citations

May 25, 2010·Journal of Nutritional Science and Vitaminology·Guangchen SunShojiro Kyotani
Dec 29, 2010·Journal of Natural Medicines·Kazuyo MuramotoHideto Kaba
Feb 2, 2008·Biological & Pharmaceutical Bulletin·Daisuke TakumaYutaka Nishioka
Aug 18, 2009·Bioresource Technology·Eliane M Z MichielinSandra R S Ferreira
Oct 4, 2007·The Journal of Pharmacy and Pharmacology·Guangchen SunYutaka Nishioka
May 22, 2010·The Journal of Pharmacy and Pharmacology·Saburo YoshiokaYutaka Nishioka
Oct 30, 2007·The American Journal of Chinese Medicine·Alberto Jorge Eraso, Inés Albesa
Dec 9, 2016·International Journal of Molecular Sciences·Yilong LiuXian Li
Nov 19, 2011·Pharmacognosy Reviews·Mohammad Ali, Nisha Chaudhary
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Khader Syed Zameer AhmedRadhakrishnan Krishnaveni

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