SCC4 cell monolayers as an alternative sublingual barrier model: influence of nanoencapsulation on carvedilol transport

Drug Development and Industrial Pharmacy
Paula Dos Santos ChavesR C R Beck

Abstract

To evaluate, for the first time, the use of SCC4 cell monolayers as an alternative sublingual barrier model and study the influence of nanoencapsulation on carvedilol transport across SCC4 cell monolayers. The sublingual cavity is an interesting route for administration of drugs with limited oral bioavailability due to hepatic first pass metabolism. By this route, the drug is directly absorbed into blood circulation. In this sense, mucoadhesive carvedilol-loaded nanocapsules (CAR-NC) were previously proposed for the administration of this drug by sublingual route. Carvedilol is used for cardiovascular diseases and suffers metabolism in liver when orally administrated. Nanoencapsulation of carvedilol controlled its permeation across porcine sublingual mucosa. Carvedilol-loaded cationic nanocapsules were prepared by interfacial deposition of a preformed polymer. Drug permeation studies were carried out in Transwell® inserts. The integrity of cell monolayers after the drug transport was assessed by transepithelial electric resistance. Compatibility of the CAR-NC with the SCC4 cells was evaluated by the Sulforhodamine B assay. The drug permeated the cell monolayer by a controlled way when nanoencapsulated and this profile had a lin...Continue Reading

References

May 1, 1994·Clinical Pharmacokinetics·T Morgan
Apr 5, 2007·Nature Protocols·Vanicha Vichai, Kanyawim Kirtikara
Dec 10, 2008·Critical Reviews in Therapeutic Drug Carrier Systems·Tarun GoswamiXiaoling Li
Nov 1, 2012·Small·Birgit Johanna TeublEva Roblegg
Jan 8, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Birgit J TeublEva Roblegg
Jan 26, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Paula Dos Santos ChavesRuy Carlos Ruver Beck

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