Scene construction impairments in Alzheimer's disease - A unique role for the posterior cingulate cortex

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Muireann IrishJohn R Hodges

Abstract

Episodic memory dysfunction represents one of the most prominent and characteristic clinical features of patients with Alzheimer's disease (AD), attributable to the degeneration of medial temporal and posterior parietal regions of the brain. Recent studies have demonstrated marked impairments in the ability to envisage personally relevant events in the future in AD. It remains unclear, however, whether AD patients can imagine fictitious scenes free from temporal constraints, a process that is proposed to rely fundamentally upon the integrity of the hippocampus. The objective of the present study was to investigate the capacity for atemporal scene construction, and its associated neural substrates, in AD. Fourteen AD patients were tested on the scene construction task and their performance was contrasted with 14 age- and education-matched healthy older Control participants. Scene construction performance was strikingly compromised in the AD group, with significant impairments evident for provision of contextual details, spatial coherence, and the overall richness of the imagined experience. Voxel-based morphometry analyses based on structural MRI revealed significant associations between scene construction capacity and atrophy i...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Mar 13, 1998·Annual Review of Psychology·D L SchacterW Koutstaal
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Sep 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M A Conway
Sep 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E A Maguire
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Dec 26, 2001·Annual Review of Psychology·Endel Tulving
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Aug 11, 2004·Trends in Cognitive Sciences·Georg Northoff, Felix Bermpohl
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Mar 23, 2005·Brain and Language·Anh DuongBernadette Ska
Aug 2, 2005·Trends in Cognitive Sciences·Anthony D WagnerRandy L Buckner
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Jun 30, 2006·Neuropsychologia·Eva SvobodaBrian Levine
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Nov 15, 2006·Neuropsychology·David A GalloAndrew E Budson
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karl K SzpunarKathleen B McDermott
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Demis HassabisEleanor A Maguire
Mar 27, 2007·Trends in Cognitive Sciences·Roberto Cabeza, Peggy St Jacques
Jun 6, 2007·Trends in Cognitive Sciences·Demis Hassabis, Eleanor A Maguire
Aug 21, 2007·Nature Reviews. Neuroscience·Daniel L SchacterRandy L Buckner
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Demis HassabisEleanor A Maguire
Aug 16, 2008·Brain Research·Anna AbrahamD Yves von Cramon
Jun 6, 2009·Neuropsychologia·Donna Rose AddisDaniel L Schacter
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Demis Hassabis, Eleanor A Maguire
Oct 9, 2009·Nature Reviews. Neuroscience·Seralynne D VannEleanor A Maguire
Feb 6, 2010·Neuropsychologia·Jennifer J SummerfieldEleanor A Maguire
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Muireann IrishRobert F Coen
Mar 2, 2010·Neuron·Jessica R Andrews-HannaRandy L Buckner
Apr 9, 2010·Physics of Life Reviews·Alisha C Holland, Elizabeth A Kensinger
Jun 22, 2010·Journal of the International Neuropsychological Society : JINS·Daniel L Greenberg, Mieke Verfaellie
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Larry R SquireKristin N Mauldin
Nov 10, 2010·Psychology and Aging·Brendan GaesserDaniel L Schacter
Mar 19, 2011·Neuropsychologia·Janine M CooperEleanor A Maguire
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sinéad L Mullally, Eleanor A Maguire

❮ Previous
Next ❯

Citations

Jun 3, 2016·Frontiers in Behavioral Neuroscience·Muireann IrishOlivier Piguet
Apr 26, 2018·Journal of Neuropsychology·Cherie Strikwerda-BrownMuireann Irish
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Siddharth RamananMuireann Irish
May 22, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shirin SalimiJames R Burrell
Apr 6, 2020·Social Cognitive and Affective Neuroscience·Isabella C WagnerClaus Lamm
Jul 8, 2018·Nature Reviews. Neurology·Gillian CoughlanMichael Hornberger
Feb 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Claire O'CallaghanMuireann Irish
Jun 19, 2019·Learning & Memory·Siddharth RamananMuireann Irish
Jan 11, 2019·Translational Vision Science & Technology·Dong-Yi LanYi Shao
Jan 29, 2019·CNS Spectrums·Julie L JiMartina Di Simplicio
Jun 27, 2018·The Journal of Headache and Pain·Mengmeng MaLi He
Oct 28, 2019·Frontiers in Genetics·Xia-An BiYingchao Liu
Feb 24, 2021·Trends in Cognitive Sciences·Federica Conti, Muireann Irish
Mar 6, 2021·IScience·Jonathan SmallwoodElizabeth Jefferies

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.