PMID: 2862956Aug 5, 1985

SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase

Brain Research
P OnaliG L Gessa

Abstract

The intraperitoneal administration of SCH 23390, a selective D1 receptor antagonist, produced catalepsy and increased the firing rate of dopamine (DA) neurons in the substantia nigra (SN-DA neurons). Maximal increase (110%) was of the same magnitude as that produced by a supramaximal dose of haloperidol, which produced no additional activation over that produced by SCH 23390. Contrary to haloperidol, SCH 23390 failed to increase the affinity of tyrosine hydroxylase (TH) for the pteridine cofactor and produced only a modest increase (30%) in DA synthesis. Moreover, SCH 23390 did not prevent haloperidol-induced activation of either TH or DA synthesis. It is concluded that blockade of postsynaptic D1 receptors results in the stimulation of SN-DA neurons, but this effect fails to activate TH and DA synthesis unless presynaptic DA autoreceptors are blocked.

References

Oct 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·T ZetterströmU Ungerstedt
Oct 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·C F Saller, A I Salama
Jan 1, 1993·Psychopharmacology·W R Klemm
Jan 1, 1993·Progress in Biophysics and Molecular Biology·M Fillenz
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·S Puglisi-Allegra, S Cabib
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·J BruhwylerM Mercier
Oct 1, 1990·Trends in Pharmacological Sciences·J HietalaE Syvälahti
Jan 1, 1987·Neurochemistry International·P Seeman, D Grigoriadis
Apr 4, 1997·European Journal of Pharmacology·S ChoM Hadjiconstantinou
Mar 1, 1990·Journal of Neurochemistry·Z L RossettiM Hadjiconstantinou

Citations

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J N Joyce
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
May 18, 1984·European Journal of Pharmacology·R B MailmanD L Dehaven
Aug 5, 1983·European Journal of Pharmacology·A H TissariG L Gessa
Jul 10, 1980·Nature·M SchachterR Dorow

Related Concepts

August Rats
Neurons
Lentiform Nucleus Structure
Synaptic Transmission
Substantia Nigra Structure
Catalepsy
Brain Chemistry
Electrophysiology (Science)
Injections, Intraperitoneal
Dopamine Receptor

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.