Schedule-controlled operant behavior of rats following oral administration of perchloroethylene: time course and relationship to blood and brain solvent levels

Journal of Toxicology and Environmental Health
D A WarrenC E Dallas

Abstract

Previous studies have indicated that human exposure to perchloroethylene (PCE) produces subtle behavioral changes and other neurological effects at concentration at or below the current occupational exposure limit. Since comparable effects in animals may be reflected by changes in schedule-controlled operant behavior, the ability of orally administered PCE to alter fixed-ratio (FR) responding for a food reward was investigated in male Sprague-Dawley rats. Furthermore, since behavioral effects of solvents are likely to be more closely related to blood or target tissue (i.e, brain) concentrations than administered dose, the relationship between the pharmacokinetic distribution of PCE and its effects on operant responding was also evaluated. Rats trained to lever-press for evaporated milk on an FR-40 reinforcement schedule were gavaged with 160 or 480 mg/kg PCE and immediately placed in an operant test cage for 90 min. Separate animals gavaged with equivalent doses of PCE were used to determine profiles of blood and brain concentrations versus time. Perchloroethylene produced changes in responding that varied not only with dose but also among animals receiving the same dose. Changes in the response rates of rats receiving 160 mg/k...Continue Reading

Citations

Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·Philip J BushnellRobert Klinger
Oct 20, 1998·Journal of Toxicology. Clinical Toxicology·M OnofrjD Rotilio
Feb 18, 2014·Environmental Health Perspectives·Kathryn Z GuytonWeihsueh A Chiu
Jun 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·William K BoyesJane Ellen Simmons
Feb 20, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathaniel C RiceTodd M Myers

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