PMID: 9536460Apr 16, 1998Paper

Schedule-controlled operant behavior of rats during 1,1,1-trichloroethane inhalation: relationship to blood and brain solvent concentrations

Neurotoxicology and Teratology
D A WarrenC E Dallas

Abstract

The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Therefore, Sprague-Dawley rats trained to lever-press for evaporated milk on a variable interval 30-s reinforcement schedule were placed in an operant test cage and exposed to clean air for 20 min, followed by a single concentration of TRI vapor (500-5000 ppm) for 100 min. Additional rats were exposed to equivalent TRI concentrations for 10, 20, 40, 60, 80, or 100 min to determine blood and brain concentration vs. time profiles. Inhalation of 1000 ppm slightly increased operant response rates, whereas 2000, 3500, and 5000 ppm decreased operant response rates in a concentration- and time-dependent manner. Accumulation of TRI in blood and brain was rapid and concentration dependent, with the brain concentration roughly twice that of blood. Plots of blood and brain TRI concentrations against operant performance showed responding in excess of control rates at low concentrations, and decreasing response rates as concentra...Continue Reading

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Citations

Nov 24, 1999·Neurotoxicology and Teratology·C N ColemanS E Robinson
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·G D RitchieD W Wright
Jun 15, 2004·Journal of Toxicology and Environmental Health. Part a·James V BrucknerJeffrey W Fisher
Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·Philip J BushnellRobert Klinger
Sep 30, 2003·Journal of Toxicology and Environmental Health. Part a·Cécil J W MeulenbergHenk P M Vijverberg
Apr 3, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vernon A BenignusElaina M Kenyon
Dec 1, 2014·Cellular and Molecular Neurobiology·Tania Campos-OrdonezOscar Gonzalez-Perez

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