PMID: 8745Jan 1, 1976

Schedule of protein ingestion and circadian rhythm of certain hepatic enzyme activities involved in glucose metabolism in the rat

Nutrition and Metabolism
J PeretG Pascal


The circadian rhythms of liver glycogen, plasma glucose, corticosterone and insulin, and hepatic activity of PK, G6PDH, ME, Ac, CoA carbox. PEP-CK and GPT were studied in adult rats. Animals either received a mixed diet ad libitum (8% protein) or a protein meal (1.1 g protein) given at 05:00 or 17:00 h, with free access to a protein-free diet (separately fed). When the protein meal was ingested during the lighted period (17:00) the 24-hour average level of liver PEP-CK was greater than in rats consuming protein during darkness (05:00). In the latter case, modification of the circadian rhythm of liver glycogen and of circadian rhythm of liver PK, G6PDH, ME and Ac.CoA carbox. activity (increase of 24 h average level, extension of period of high activity, sudden increase after ingestion of protein meal) were observed. Conversely, the circadian rhythm of plasma insulin and corticosterone and of liver PEP-CK and GPT activity were only slightly affected by the mode of feeding.


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Aug 21, 2012·Circulation Research·Maha Abdellatif
Jun 15, 2014·The Journal of Endocrinology·Shannon M BaileyMartin E Young
Sep 1, 1994·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J M FuentesJ A Madrid
Mar 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J M Gómez-SierraM Alemany
Jul 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·L D Berrizbeitia, F D Moore
Jan 1, 1985·Diabetes/metabolism Reviews·D K Granner, T L Andreone
Jun 11, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Alec J DavidsonFriedrich K Stephan

Related Concepts

Acetyl-CoA Carboxylase
SGPT - Glutamate pyruvate transaminase
Blood Glucose
Circadian Rhythms
Glucosephosphate Dehydrogenase

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