Schema-like learning and memory consolidation acting through myelination

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Mahadi HasanYing Li

Abstract

Memory is a dynamic brain function that is continually processed after encoding. Although psychologic concepts of mental schema are now well established, they have rarely been considered in animal studies. We used a behavior paradigm of multiple flavor-place paired associates (PAs) and showed that memory schema facilitates fast acquisition of new PAs in a single trial. The hippocampus is necessary for the encoding of new PAs and for memory retrieval within a certain time window-24 h following new PA consolidation. Whereas the anterior cingulate cortex (ACC) plays a critical role for dynamic PA learning and consolidation during training sessions, ACC is essential in schema representation and activation. New myelin generation is essential for learning. Neural activity in the cortical regions impacts myelination by regulating oligodendrocyte (OL) proliferation, differentiation, and myelin formation. Here, we show that newly formed OL progenitor cells and mature OLs are increased following repeated PA learning and that establishment of the memory schema is associated with enhanced myelin strength in the ACC region. Furthermore, to ensure that myelination is necessary for the acquisition of paired-associate learning, ACC lysolecithi...Continue Reading

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Citations

Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Svenja Brodt, Steffen Gais
Sep 22, 2020·Brain and Neuroscience Advances·Alejandra AlonsoLisa Genzel
Oct 18, 2020·International Journal of Molecular Sciences·Alessandra RoggeriTim Vanmierlo
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May 4, 2021·Frontiers in Cellular Neuroscience·Myriam CayrePascale Durbec
Jun 15, 2021·Neurotoxicology and Teratology·Brandon VelascoCarmen Sato-Bigbee

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Methods Mentioned

BETA
Protein Assay
electron microscopy

Software Mentioned

Offline Sorter
OmniPlex
Prism
NeuroExplorer
Matlab
SPSS
GraphPad
ImageJ

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