PMID: 8587799Jan 1, 1996Paper

Schistosoma: analysis of monoclonal antibodies reactive with the circulating antigens CAA and CCA

Parasitology
A M DeelderR J Van Zeyl

Abstract

Using spleen cells of mice infected or immunized respectively with cercariae or antigen preparations of Schistosoma mansoni, S. haematobium or S. japonicum monoclonal antibodies (mAbs) were produced against the schistosome gut-associated antigens CAA (circulating anodic antigen) and CCA (circulating cathodic antigen). Fusions nearly exclusively produced either anti-CAA (n = 25) or anti-CCA mAbs (n = 55) with a strong isotype restriction (IgM, IgG1 and IgG3) against both antigens, the majority of anti-CAA mAbs being IgG1 and the majority of anti-CCA mAbs being IgM. The mAbs, which on the basis of their selection were reactive with multiple carbohydrate epitopes of CAA or CCA, were applied in different immunological techniques including immunofluorescence, a dot immunobinding assay and immunoelectrophoresis to study the epitope repertoire. Anti-CAA mAbs were found to be reactive with 5 different epitopes, none of which occurred as multiple epitopes on eggs. Anti-CCA mAbs, on the other hand, recognized at least 10 different epitopes, while 44% of anti-CCA mAbs recognized epitopes common to the adult worm and the egg. Both CAA- and CCA-epitopes were found to be developmentally expressed at the level of the tegument in cercariae, sc...Continue Reading

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Citations

Jan 9, 2004·Journal of Biotechnology·Oleg A MayborodaAndré M Deelder
Mar 20, 2012·Parasitology·Angela van DiepenCornelis H Hokke
Dec 8, 2004·Journal of Clinical Microbiology·G J van DamA M Deelder
Mar 29, 2006·European Biophysics Journal : EBJ·Victor V SkakunOleg A Mayboroda
Jan 29, 2009·Proteins·Daniël C de GeusJan Pieter Abrahams
Nov 26, 1999·Biochimica Et Biophysica Acta·R D Cummings, A K Nyame
Jan 18, 2011·International Journal for Parasitology·Saskia DewalickJaap J van Hellemond
Aug 15, 2014·PLoS Pathogens·Patrick J SkellyR Alan Wilson
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Daniel G ColleySue Binder
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Paul L A M CorstjensGovert J van Dam

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