PMID: 2114011Jun 1, 1990Paper

Schistosoma haematobium infection in Mauritania: two years of follow-up after a targeted chemotherapy--a life-table approach of the risk of reinfection

Parasitology
J F EtardC Segala

Abstract

Reinfection pattern among 6- to 20-year-old subjects was studied over 24 months in two Mauritanian villages of intense Schistosoma haematobium infection after a targeted chemotherapy with praziquantel involving the whole community. Subjects received treatment according to the presence of haematuria/proteinuria and this indirect screening technique was able to identify 98-100% of the heavily infected subjects (50 + eggs/10 ml). The two villages differed with respect to their characteristics, quality of follow-up and reinfection pattern. The post-treatment 6-month cumulative incidence during the two transmission periods following the chemotherapy, estimated from a subset of 116 subjects, was 18.0% and 20.5%. Reinfection rates were higher among males (Cox-Mantel: P = 0.0015), among children 6-10 years of age than older (P = 0.0078) and among subjects with more than 50 eggs/10 ml of urine before treatment than subjects with a lower egg output (P = 0.009). A Cox proportional hazard regression model was fitted and confirmed that gender, age and pretreatment level of infection were predictors of the rate of reinfection but that there was no interaction between these predictors.

References

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·R F SturrockT K arap Siongok
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A WilkinsS Tulloch
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Bensted-SmithR F Sturrock
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·G A TingleyR F Sturrock
Sep 1, 1984·The American Journal of Tropical Medicine and Hygiene·L S StephensonM L Oduori
Mar 1, 1989·Parasitology Today·H A Wilkins

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Citations

May 29, 2000·Annals of Tropical Medicine and Parasitology·V R SouthgateJ Vercruysse
Oct 9, 2004·Trends in Parasitology·Simon BrookerRoy M Anderson
Sep 12, 2014·PLoS Neglected Tropical Diseases·Evaristus Chibunna MbanefoKenji Hirayama
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·D De ClercqJ Vercruysse

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