Schistosoma japonicum: an ultraviolet-attenuated cercarial vaccine applicable in the field for water buffaloes

Experimental Parasitology
Y E ShiA Ruppel

Abstract

Water buffaloes were vaccinated three times with 10,000 Schistosoma japonicum cercariae irradiated with ultraviolet (uv) light at a dose of 400 microW x min/cm2. The irradiation was performed with cheap, simple, and portable equipment in a rural area of Hubei Province (People's Republic of China). A challenge infection of 1000 untreated cercariae was given to six vaccinated and six naive control buffaloes, while two vaccinated animals were not challenged. The experiment was terminated 6 weeks after the challenge. Control animals had lost body weight and harbored a mean of 110 worms and 37 eggs per gram of liver. The vaccinated animals gained weight after the challenge and developed 89% resistance to infection with S. japonicum. Since schistosomiasis japonica is nowadays transmitted in China predominantly by domestic livestock, a uv-attenuated cercarial vaccine for bovines may contribute to the control of this disease.

References

Oct 15, 1988·Experientia·J Eckert
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·N A MoloneyG Webbe
Feb 7, 1970·The Veterinary Record·D PoynterH C Menear
Feb 1, 1988·Parasitology Today·R L SharmaD N Dhar

❮ Previous
Next ❯

Citations

Nov 15, 2011·Parasitology Research·Jie YangZhongdao Wu
Mar 1, 1996·International Journal for Parasitology·M HopeD P McManus
Jun 26, 2001·Trends in Parasitology·Y X HeK Ramaswamy
Aug 25, 2004·Trends in Parasitology·Andreas RuppelMahmoud Bahgat
Jun 13, 1998·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·L ShuxianP J Hotez
Nov 2, 2014·Parasitology·Hong You, Donald P McManus
May 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G J Waine, D P McManus
Sep 20, 2019·PLoS Neglected Tropical Diseases·Lucinda HazellMichael R Templeton
Oct 3, 2018·Tropical Medicine and Infectious Disease·Hong YouDonald P McManus
Apr 3, 2018·PLoS Neglected Tropical Diseases·Laura BraunMichael R Templeton
Jul 7, 2021·PLoS Neglected Tropical Diseases·Lucinda HazellMichael R Templeton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.