PMID: 9177096Jun 24, 1997Paper

Schistosoma japonicum infection in the pig: the effect of a patent primary infection on a challenge infection

Acta Tropica
A L WillinghamP Nansen

Abstract

The response of pigs to a challenge infection of Schistosoma japonicum following a primary infection was assessed using parasitological parameters and eosinophil counts. Twenty-five Danish Landrace/Yorkshire/Duroc crossbred pigs were divided into four groups. Group A (n = 10) received a primary infection, group B (n = 5) received both a primary and challenge infection, group C (n = 5) received a challenge control infection and group D (n = 5) received no infection serving as helminth-free controls. A dose of 850 cercariae was administered by intramuscular injection at the primary infection (week 0) and challenge infection (week 12). The pigs were perfused at week 21, except for half of the group A pigs which were slaughtered at week 12. Challenge infection did not result in higher worm burdens or tissue egg counts in group B than group A at week 21 and mature/immature worm ratios were similar for the two groups. In addition, no increases in faecal egg counts or eosinophil counts were observed in group B after challenge infection. The results indicate that pigs are able to mount a very rapid and effective response to reinfection with S. japonicum following a patent primary infection resulting in prevention of establishment of ch...Continue Reading

References

Jan 1, 1975·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J Pitchford, P S Visser
Aug 1, 1992·Immunological Investigations·A E ButterworthR F Sturrock
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·N A MoloneyG Webbe
Jun 1, 1987·Acta Tropica. Supplementum·A E Butterworth
Jul 1, 1996·Journal of Comparative Pathology·M V JohansenR Lindberg
Apr 1, 1996·Parasitology Today·A L Willingham, M Hurst

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Citations

Jul 7, 1999·Veterinary Parasitology·H GiverP Nansen
Oct 11, 2003·Parasitology International·Andrew R ButcherDavid I Grove
Sep 23, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi-Xin LiuYi-Xin Huang

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