Abstract
The role of exposed surface carbohydrates in chemoreception in Schistosoma mansoni females was investigated in vitro. Sexually mature females were treated with peanut (PNA), soybean (SBA) or wheat germ (WGA) agglutinin, and their migration in response to excretory-secretory (ES) products of males was measured in a bioassay system. Random distribution of untreated and lectin-treated females was similar (p=>0.05). PNA-treated females were unresponsive for 1.0 h, after which they exhibited slight repulsion to ES products. SBA-treated females did not respond to ES products for 3.0 h. WGA-treated females were unresponsive for 1.5h, after which they exhibited slight attraction to male ES products. Attempts were made to restore chemoattraction by using specific sugar inhibitors of lectin-binding; chemoattraction was best restored in n-acetyl-d-galactosamine (GalNAc)-treated females. These data suggest that GalNAc-containing receptors, possibly GP50, the major SBA-binding schistosome glycan, mediate chemoreception in schistosome females. These findings may explain the observed differences in morbidity between individuals with different blood groups. Individuals with blood group B or O may afford partial protection because of their natu...Continue Reading
References
Dec 1, 1978·Experimental Parasitology·K D MurrellD A Dean
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·D CamusF Santoro
Sep 15, 1991·Experientia·M A Haseeb, L K Eveland
Mar 15, 1989·Experientia·L K Eveland, M A Haseeb
Feb 1, 1985·International Journal for Parasitology·M A HaseebM A Hayat
Aug 1, 1985·Molecular and Biochemical Parasitology·A N MacGregorJ R Kusel
Jun 1, 1973·Experimental Parasitology·P C Stein, R D Lumsden
Oct 1, 1983·Experimental Parasitology·L K EvelandL M Cohen
Feb 1, 1984·Experimental Parasitology·A P Norden, M Strand
Feb 1, 1984·International Journal for Parasitology·M A HaseebB Fried
Dec 1, 1982·Parasitology·E Linder, G Huldt
Feb 1, 1982·Experimental Parasitology·A J Simpson, D J McLaren
Oct 1, 1982·Experimental Parasitology·L K EvelandL M Cohen
Sep 21, 2000·Acta Tropica·L ChitsuloL Savioli
Apr 19, 2002·The New England Journal of Medicine·Allen G P RossDonald P McManus
Jul 20, 2006·Microbes and Infection·Amr M GhalebRaymond T Damian
Aug 1, 1986·Journal of Chemical Ecology·B Fried
Aug 1, 1986·Journal of Chemical Ecology·L K Eveland, M A Haseeb
Aug 1, 1986·Journal of Chemical Ecology·J E ChildsE L Schiller
Aug 1, 1986·Journal of Chemical Ecology·E G Hayunga, M P Sumner
Citations
Jan 5, 2013·Journal of Helminthology·A DegaregeB Erko
Feb 22, 2012·Acta Tropica·Maha F M Soliman
Apr 18, 2015·BMC Public Health·Abraham DegaregeBerhanu Erko
Mar 21, 2009·International Journal for Parasitology·Michelle L Steinauer
May 20, 2016·Journal of Helminthology·A DegaregeB Erko
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling