PMID: 3129691Feb 1, 1988Paper

Schistosoma mansoni: evidence that eosinophils and/or macrophages contribute to skin-phase challenge attrition in vaccinated CBA/Ca mice

R E Ward, D J McLaren


Naive CBA mice and mice vaccinated 4 weeks previously with gamma-irradiated cercariae were challenged percutaneously with normal cercariae and the skin site of challenge removed at various times to provide samples for histological examination. Neutrophil abscesses surrounding schistosomula as well as cast cercarial tails were identified at the skin surface in both naive/challenged and vaccinated/challenged mice. The dermis in both groups of animals became infiltrated with mononuclear cells and granulocytes. Neutrophils were the predominant granulocyte in naive/challenged skin but eosinophils replaced neutrophils by 48 h post-challenge in skin from vaccinated mice. Schistosomula with adherent mononuclear cells and granulocytes were identified preferentially in the dermis of vaccinated mice; such larvae frequently exhibited subtegumental vacuolation. A further major characteristic of vaccinated/challenged skin was the formation, from 18 h, of extensive subdermal inflammatory foci, consisting of up to 50% mononuclear cells and 50% eosinophils. These foci invariably surrounded one or more larval parasites which were seen by both optical and scanning electron microscopy to have a morphology typical of lung stage rather than skin sta...Continue Reading


Sep 8, 1977·Nature·D J McLaren, D J Hockley
Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Jan 1, 1973·International Journal for Parasitology·D J Hockley, D J McLaren
Aug 1, 1984·Parasitology·D J McLaren
Apr 1, 1982·Experimental Parasitology·D J McLaren, R N Incani
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry
Jul 1, 1981·The American Journal of Tropical Medicine and Hygiene·A G BentleyS M Phillips
Aug 1, 1981·Molecular and Biochemical Parasitology·F D Rumjanek, D J McLaren
Nov 1, 1980·The American Journal of Tropical Medicine and Hygiene·A M Savage, D G Colley


Apr 1, 1993·International Journal for Parasitology·K P Piper, D J McLaren
Jan 1, 1992·Scandinavian Journal of Immunology. Supplement·G KimaniG M Mkoji
Sep 10, 2005·Parasite Immunology·L M Ganley-LealW E Secor
Apr 20, 2018·Frontiers in Immunology·Claudia Cristina MotranLaura Cervi

Related Concepts

Mice, Inbred CBA
Scanning Electron Microscopy
Schistosoma mansoni
Schistosomiasis Mansoni
Vaccines, Attenuated

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