PMID: 3124065Nov 1, 1987Paper

Schistosoma mansoni: evidence that immunity in vaccinated and chronically infected CBA/Ca mice is sensitive to treatment with a monoclonal antibody that depletes cutaneous effector cells

Parasite Immunology
D J McLarenS R Smithers


Naive mice, mice vaccinated 4 weeks previously with radiation-attenuated cercariae of Schistosoma mansoni and mice infected 16 weeks previously with normal S. mansoni cercariae were treated with a rat monoclonal antibody (NIMP-R14), that has been reported elsewhere to recognize neutrophils selectively. The establishment of a primary schistosome population in naive mice was not affected by the administration of this reagent. In contrast, immune-dependent challenge elimination was reduced in both vaccinated and chronically infected mice following treatment with NIMP-R14. Maximal suppression of resistance in both vaccinated (67% mean reduction) and chronically infected (44% mean reduction) mice was achieved when NIMP-R14 was injected intraperitoneally on the day of challenge. The monoclonal was markedly less effective when administered on or after day 3. Analysis of the blood leucocyte profiles of vaccinated/NIMP-R14 treated mice showed that the monoclonal totally abrogated neutrophils from the peripheral circulation between days 1 and 6. Histological examination of the skin site of challenge revealed, however, that NIMP-R14 treatment had reduced the number of eosinophils and macrophages as well as neutrophils in the cutaneous tis...Continue Reading


Oct 1, 1985·The Australian Journal of Experimental Biology and Medical Science·I A PentillaC R Jenkin
Jul 1, 1984·British Journal of Haematology·A F LopezC J Sanderson


Apr 1, 1993·International Journal for Parasitology·K P Piper, D J McLaren
Dec 1, 1989·Immunology Today·D A VignaliM G Taylor
Jan 27, 2004·The Journal of Parasitology·Ariela Freudenstein-DanZvi Fishelson
Sep 7, 2007·Kidney International·A L RopsJ van der Vlag
Jun 24, 2004·European Journal of Pharmacology·Tijl De CelleBen J Janssen
Jul 1, 1989·Parasite Immunology·A FlisserD J McLaren
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·Denise Silveira-LemosRodrigo Corrêa-Oliveira

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