Schistosoma mansoni: histological analysis of the synergistic interaction between vaccine immunity and praziquantel therapy in the lungs of mice

Parasite Immunology
K P PiperD J McLaren

Abstract

Naive CBA mice and mice vaccinated 4 weeks previously with gamma-irradiated cercariae of S. mansoni were challenged percutaneously with normal cercariae and then treated with 500 mg/kg body weight of Praziquantel (Pzq). The drug was administered intradermally on day 1 or intramuscularly on day 6, thus targeting against skin stage or lung stage challenge larvae respectively. The skin site of challenge and/or the lungs were removed at various time points to provide samples for histological examination. As reported elsewhere (Flisser, Delgado & McLaren 1989) the efficacy of Pzq was significantly enhanced in vaccinated mice and was influenced by the treatment regime. Histological analysis revealed that when Pzq was administered I/D on day 1 to vaccinated mice, the inflammatory response to challenge differed in extent but not nature from that seen in vaccinated but untreated cohorts. This correlates with worm recovery data showing no (this study), or only marginal synergy between drug treatment and immunity using this regimen of drug treatment (Flisser et al. 1989). Following the day 6 protocol of drug delivery, however, lungs from treated vaccinated mice exhibited many large inflammatory reactions containing trapped challenge larva...Continue Reading

References

Jul 1, 1989·Parasite Immunology·A FlisserD J McLaren
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R LambertucciM J Doenhoff
Nov 1, 1987·The American Journal of Tropical Medicine and Hygiene·R AitkenR A Wilson
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
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Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
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Citations

Jan 1, 1992·Parasitology
Apr 16, 2013·Parasitology International·Hanan F Aly, Mona Mohamed Mantawy
Jul 15, 2011·Revista Do Instituto De Medicina Tropical De São Paulo·Mona Mohamed MantawyMaha Zaki Rizk
Oct 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L JohanssonM Albin
Jan 1, 1992·Parasitology·P G FallonM J Doenhoff

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