Schistosoma mansoni infection in mice augments the capacity for interleukin 3 (IL-3) and IL-9 production and concurrently enlarges progenitor pools for mast cells and granulocytes-macrophages.

Infection and Immunity
R M KhalilL Hültner

Abstract

Mast cells and granulocytes-macrophages (GM) are components of the host defense system against worm infections, including schistosomiasis. Here we report the kinetics of changes in the number of colony-forming cells (CFC) for mast cells and GM during the course of a primary experimental infection of mice with Schistosoma mansoni cercariae over a period of 24 weeks postinfection (p.i.). Concurrently, we measured known myelopoietic and/or mast cell-stimulating cytokines (i.e., interleukin 3 [IL-3] and IL-9) in pokeweed mitogen-activated spleen cell-conditioned medium. Our results show that during the acute phase of the hepatic granulomatous reaction, the numbers of both mast-CFC and GM-CFC were significantly elevated in bone marrow. However, while femoral GM-CFC numbers had returned to normal control values at week 16 p.i., femoral and splenic mast-CFC numbers remained significantly elevated until week 20 p.i., which corresponds to the chronic fibrotic phase of hepatic granulomatous inflammation. Increased GM-CFC numbers correlated with elevated IL-3 levels, while increased mast-CFC numbers paralleled the increased IL-9 concentrations in spleen cell-conditioned medium. By the reverse transcription-PCR method, enhanced expression ...Continue Reading

References

Jan 1, 1975·The American Journal of Tropical Medicine and Hygiene·A W Senft, S E Maddison
Jun 11, 1992·Immunological Reviews·J F UrbanF D Finkelman
Jul 1, 1992·The Journal of Clinical Investigation·D W PenningtonW M Gold
Feb 1, 1991·The Journal of Experimental Medicine·L Thompson-SnipesD M Rennick
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Jan 1, 1989·The Journal of Experimental Medicine·J Van SnickR J Simpson
Jan 1, 1987·International Archives of Allergy and Applied Immunology·C MazingueB M Stadler
Jan 1, 1987·International Archives of Allergy and Applied Immunology·A M AttallahW E Vannier
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C UyttenhoveJ Van Snick
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Sep 1, 1969·Experimental Parasitology·G GazzinelliW D da Silva
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·B A CattoE A Ottesen
Aug 1, 1995·Current Opinion in Immunology·T A Wynn, A W Cheever
Jul 1, 1994·Parasite Immunology·A J BancroftE Devaney

❮ Previous
Next ❯

Citations

Nov 10, 2010·European Journal of Immunology·Jo A Van GinderachterGeert Raes
Sep 24, 2005·Histopathology·A M Ahmed El-Refaie, A D Burt
Dec 3, 2016·Seminars in Immunopathology·P Licona-LimónE Olguín-Martínez
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L HültnerE Schmitt
Jul 30, 2014·Frontiers in Immunology·Masoud H ManjiliScott Abrams
Mar 24, 2021·Biological Reviews of the Cambridge Philosophical Society·Kássia K MaltaRossana C N Melo
Mar 7, 2014·Molecular Immunology·Joakim S Dahlin, Jenny Hallgren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.