Schistosoma mansoni Infection in Ugandan Men Is Associated with Increased Abundance and Function of HIV Target Cells in Blood, but Not the Foreskin: A Cross-sectional Study

PLoS Neglected Tropical Diseases
Jessica ProdgerR Kaul

Abstract

Schistosoma mansoni infection has been associated with an increased HIV prevalence in humans and SHIV incidence in primate models. We hypothesized that immune activation from this gastrointestinal mucosa infection would increase highly HIV-susceptible CD4 T cell subsets in the blood and the foreskin through common mucosal homing. Foreskin tissue and blood were obtained from 34 HIV- and malaria-uninfected Ugandan men who volunteered for elective circumcision, 12 of whom were definitively positive for S. mansoni eggs in stool and 12 definitively negative for both S. mansoni eggs and worm antigen. Tissue and blood T cell subsets were characterized by flow cytometry and immunohistochemistry (IHC). Th17 and Th1 cells from both the blood and foreskin expressed higher levels of CCR5 and were more activated than other CD4 T cell subsets. S. mansoni-infected men had a higher frequency of systemic Th1 cells (22.9 vs. 16.5% of blood CD4 T cells, p<0.05), Th17 cells (2.3 vs. 1.5%, p<0.05), and Th22 cells (0.5 vs. 0.3%, p<0.01) than uninfected men. Additionally, Th17 cells in the blood of S. mansoni-infected men demonstrated enhanced function (28.1 vs. 16.3% producing multiple cytokines, p = 0.046). However, these immune alterations were no...Continue Reading

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Citations

Jul 3, 2018·PLoS Neglected Tropical Diseases·Soledad ColombeJennifer A Downs
Oct 17, 2018·Infection and Immunity·Kathryn M DupnikJennifer A Downs
Dec 5, 2019·Tropical Diseases, Travel Medicine and Vaccines·Sergey YegorovRupert Kaul
Feb 4, 2021·International Journal of STD & AIDS·Supriya D MehtaRupert Kaul

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Methods Mentioned

BETA
circumcision
RSA
density gradient centrifugation
ELISA
flow cytometry

Software Mentioned

SPICE
SPSS
FlowJo
Excel

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