PMID: 1660590Oct 1, 1991Paper

Schistosoma mansoni: larval damage and role of effector cell(s) in the synergy between vaccine immunity and praziquantel treatment

Parasitology
K P PiperD J McLaren

Abstract

A number of authors have demonstrated that the schistosomicidal compound, Praziquantel (Pzq), depends for its action upon the immune status of the host (Sabah et al. 1985; Brindley & Sher, 1987; Doenhoff et al. 1987). We have attempted to define the synergistic interaction between immuno- and chemotherapy further, using the murine irradiated vaccine model of schistosomiasis mansoni. In vaccinated mice, resistance operates in the skin but not the lungs; drug targeted towards lung-stage worms exacerbates lung-phase immunity, however, as depicted by the increased number and size of inflammatory reactions in the pulmonary tissues. Parasites are often found trapped within such foci. In the present investigation, light and ultrastructural studies have been utilized to examine the nature and extent of damage inflicted upon lung-stage larvae recovered from day 6 Pzq-treated vaccinated mice. Such studies have revealed that damage involves muscle disorganization, internal disruption and occasionally, loss of the tegument; in the latter case, cells are often seen attached to the denuded lung worms. To identify the crucial cellular effector cell(s) involved in the synergy between immuno- and chemotherapy, cell depletion studies have been p...Continue Reading

References

Aug 1, 1990·Experimental Parasitology·P J Brindley, A Sher
Jul 1, 1989·Parasite Immunology·A FlisserD J McLaren
Nov 1, 1987·The American Journal of Tropical Medicine and Hygiene·R AitkenR A Wilson
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffJ Bain
Jul 9, 1987·European Journal of Pharmacology·G E DeLander, C J Hopkins
Jan 1, 1985·Pharmacology & Therapeutics·P Andrews
Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
Jan 1, 1973·International Journal for Parasitology·D J Hockley, D J McLaren
Jan 1, 1984·Advances in Pharmacology and Chemotherapy·E Groll
Jul 1, 1984·British Journal of Haematology·A F LopezC J Sanderson
Sep 1, 1980·Molecular and Biochemical Parasitology·J F Dubremetz, C Dissous
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·M K Shaw, D A Erasmus
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry

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Citations

Jan 1, 1992·Parasitology
Dec 3, 1999·Parasite Immunology·M G HernandezM L Santiago
Jan 1, 1992·Parasitology·P G FallonM J Doenhoff

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