Schistosoma mansoni: migration and attrition of challenge parasites in naive rats and rats protected with vaccine serum

Parasite Immunology
R E Ward, D J McLaren

Abstract

The migration of isotopically labelled Schistosoma mansoni challenge cercariae was monitored, by means of squashed organ autoradiography, in naive Sprague-Dawley rats and rats protected with serum harvested from twice vaccinated donors. The majority of challenge larvae migrated from the skin to the lungs in both groups of rats, but a significantly increased number of larvae was retained in the lungs of serum recipients on day 8 post-challenge. An average of 25% of the challenge population succeeded in migrating to the livers of naive rats by day 14, compared to only 13% in passively protected animals; serum recipients were shown by perfusion on day 21 to be 73% immune. Histological examination of lung tissue harvested from naive rats challenged intravenously with lung-stage schistosomes revealed small foci composed of mononuclear cells that sometimes enclosed larvae; these worms are likely to be lost due to innate resistance. In the lungs of serum-protected rats, many challenge larvae were seen to be surrounded by extensive eosinophil-enriched inflammatory foci; parasite remnants were also observed within such reactions. Ultrastructural examination of worms recovered from the lungs of passively protected animals revealed muscle...Continue Reading

References

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