Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.

World Journal of Gastroenterology : WJG
Nathalie E RuyssersTom G Moreels

Abstract

To investigate the therapeutic effect of Schistosoma mansoni (S. mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. Colitis was induced by intrarectal injection of trinitrobenzene sulphate (TNBS) and 6 h later, mice were treated ip with S. mansoni proteins. Experiments were performed 5 d after TNBS injection. Inflammation was quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility. Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up. Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. Intracolonic injection of TNBS caused severe colitis. Treatment with S. mansoni proteins significantly ameliorated colonic inflammation after 5 d. TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis. Treatment with S. mansoni proteins ameliorated these in vivo and in vitro motility disturbances. In addition, TNBS injection caused a downregulation of eff...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Dec 1, 1995·Journal of Clinical Gastroenterology·V AnneseA Andriulli
Jul 3, 1998·Gastroenterology·C Fiocchi
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Geboes, S Collins
Jul 29, 2000·Journal of Clinical Gastroenterology·F CastiglioneG Mazzacca
Nov 30, 2000·The American Journal of Gastroenterology·M Alic
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T G MoreelsP A Pelckmans
Apr 3, 2002·Archives of Surgery·Matthew D VreesWeibiao Cao
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·David E ElliottJoel V Weinstock
Dec 14, 2004·Gut·R W SummersJ V Weinstock
Apr 13, 2005·Gastroenterology·Robert W SummersJoel V Weinstock
Jun 17, 2005·Springer Seminars in Immunopathology·Joel V WeinstockDavid E Elliott
Sep 28, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T C SeerdenJ G De Man
Feb 21, 2006·Clinical and Experimental Immunology·W I Khan, S M Collins
May 16, 2006·The American Journal of Gastroenterology·Bret A Lashner, Edward V Loftus
Jun 7, 2006·Current Opinion in Pharmacology·Giorgos Bamias, Fabio Cominelli
Jun 9, 2006·Current Opinion in Gastroenterology·Jan H Niess, Hans-Christian Reinecker
Sep 6, 2006·The Journal of Medical Investigation : JMI·Nao KohnoSusumu Ito
Mar 23, 2007·BMC Gastroenterology·Jón O KristinssonJoost P H Drenth
Sep 22, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T C SeerdenB Y De Winter
Apr 18, 2008·European Journal of Pharmacology·Aletta D KraneveldJohan Garssen
May 30, 2008·Clinical & Developmental Immunology·Nathalie E RuyssersTom G Moreels
Nov 22, 2008·Inflammatory Bowel Diseases·Nathalie E RuyssersTom G Moreels
Apr 11, 2009·Gut·B StoffelsA J Bauer

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Citations

Jan 18, 2013·Clinical Reviews in Allergy & Immunology·Dana Ben-Ami ShorYehuda Shoenfeld
Jul 16, 2013·Applied and Environmental Microbiology·Jovanka LukicJelena Begovic
Mar 5, 2011·Digestive Diseases and Sciences·Keisuke FurumatsuMasaru Yoshida
Jan 21, 2015·Parasite Immunology·J O Fleming, J V Weinstock
Apr 14, 2015·Journal of Autoimmunity·Tomer BashiYehuda Shoenfeld
Dec 31, 2014·Parasitology Research·Nora L El-Tantawy
Aug 31, 2016·Inflammatory Bowel Diseases·Fernando LopesDerek M McKay
Feb 13, 2016·Memórias do Instituto Oswaldo Cruz·Patrícia d'Emery Alves SantosValdênia Maria Oliveira de Souza
Feb 14, 2019·Parasitology Research·Chun-Lian TangCun-Lan Mao
Apr 4, 2015·World Journal of Gastroenterology : WJG·Jing-Wen ZhangCai-Ming Xu

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