Schistosoma mansoni venom allergen like proteins present differential allergic responses in a murine model of airway inflammation.

PLoS Neglected Tropical Diseases
Leonardo P FariasLuciana C C Leite

Abstract

The Schistosoma mansoni Venom-Allergen-Like proteins (SmVALs) are members of the SCP/TAPS (Sperm-coating protein/Tpx-1/Ag5/PR-1/Sc7) protein superfamily, which may be important in the host-pathogen interaction. Some of these molecules were suggested by us and others as potential immunomodulators and vaccine candidates, due to their functional classification, expression profile and predicted localization. From a vaccine perspective, one of the concerns is the potential allergic effect of these molecules. Herein, we characterized the putative secreted proteins SmVAL4 and SmVAL26 and explored the mouse model of airway inflammation to investigate their potential allergenic properties. The respective recombinant proteins were obtained in the Pichia pastoris system and the purified proteins used to produce specific antibodies. SmVAL4 protein was revealed to be present only in the cercarial stage, increasing from 0-6 h in the secretions of newly transformed schistosomulum. SmVAL26 was identified only in the egg stage, mainly in the hatched eggs' fluid and also in the secretions of cultured eggs. Concerning the investigation of the allergic properties of these proteins in the mouse model of airway inflammation, SmVAL4 induced a signifi...Continue Reading

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Citations

Feb 11, 2014·Biochemical and Biophysical Research Communications·Young-Il JeongSang-Eun Lee
Jan 30, 2014·Parasites & Vectors·Rodney Hull, Zodwa Dlamini
Nov 10, 2013·PLoS Neglected Tropical Diseases·Leonardo P FariasLuciana C C Leite
Jan 1, 2014·Vaccines·Rachel StephensonIstvan Toth
May 12, 2012·International Journal for Parasitology·Henrique K RofattoLeonardo P Farias
Feb 19, 2015·Frontiers in Immunology·Edward J FarnellDavid W Dunne
Oct 30, 2015·PLoS Computational Biology·Nidhi TyagiNicholas Furnham
Jan 23, 2016·PloS One·Tianfang WangScott F Cummins
May 10, 2017·Parasites & Vectors·Rafaela Sachetto FernandesLeonardo Paiva Farias
Aug 2, 2014·Acta Crystallographica. Section D, Biological Crystallography·Alan KelleherOluwatoyin A Asojo
Jan 30, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Gyaviira NkurunungiAlison M Elliott
Jul 8, 2016·The World Allergy Organization Journal·Luis CaraballoVictoria Cardona

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Datasets Mentioned

BETA
AAW27353.1

Methods Mentioned

BETA
Protein Assay
glycosylation
electrophoresis
bronchoalveolar lavage
ELISA
PCA
glycosylations
column chromatography
Circular Dichroism

Software Mentioned

DNA2
Treeview
ClustalX
Clustal X
DNA
Compute pI / Mw

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