PMID: 15240716Jul 9, 2004Paper

Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages

The Journal of Immunology : Official Journal of the American Association of Immunologists
Philip SmithPadraic G Fallon

Abstract

Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this study we demonstrate that the trematode parasite Schistosoma mansoni has evolved with two distinct mechanisms to suppress T cell activation. During the initial 4- to 12-wk acute stages of a worm infection both CD4(+) and CD8(+) T cells are anergized. In contrast, infection with male and female worms induced T cell anergy at 4 wk, which was replaced after egg laying by T cell suppression via a known NO-dependent mechanism, that was detected for up to 40 wk after infection. Worm-induced anergy was mediated by splenic F4/80(+) macrophages (Mphi) via an IL-4-, IL-13-, IL-10-, TGF-beta-, and NO-independent, but cell contact-dependent, mechanism. F4/80(+) Mphi isolated from worm-infected mice were shown to induce anergy of naive T cells in vitro. Furthermore, naive Mphi exposed to live worms in vitro also induced anergy in naive T cells. Flow cytometry on in vivo and in vitro worm-modulated Mphi revealed that of the family of B7 costimulatory molecules, only programmed death ligand 1 (PD-L1) was selectively up-regulated. The addition of inhibitory mAb against PD-L1, but not PD-L2, to worm-modulated M...Continue Reading

References

Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J K ActorJ A Berzofsky
Jul 21, 1999·Molecular and Biochemical Parasitology·C G Grevelding
Mar 22, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M J Stadecker
Oct 18, 2000·Infection and Immunity·R A O'ConnorE Devaney
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Apr 3, 2001·The Journal of Experimental Medicine·S Y TsengH Tsuchiya
Feb 22, 2002·European Journal of Immunology·LauraL CarterBeatriz M Carreno
Apr 27, 2002·Nature Immunology·Jean-Claude D SchwartzSteven C Almo
Jul 3, 2002·Nature Reviews. Immunology·Ethan M Shevach
Jul 3, 2002·Nature Reviews. Immunology·Edward J Pearce, Andrew S MacDonald
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiHideo Yagita
Dec 10, 2002·Annual Review of Immunology·Ronald H Schwartz
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy D StrawEdward J Pearce
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia A BrownGordon J Freeman
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole Selenko-GebauerJohannes Stöckl
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·P'ng Loke, James P Allison
Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
Apr 30, 2003·The Journal of Experimental Medicine·Shengdian WangLieping Chen
Jun 11, 2003·Nature Immunology·Norihiko WatanabeKenneth M Murphy
Jun 18, 2003·The Journal of Experimental Medicine·Xingluo LiuYang Liu
Jul 9, 2003·The Journal of Experimental Medicine·Tahiro ShinFranck Housseau
Sep 2, 2003·Nature Reviews. Immunology·Rick M Maizels, Maria Yazdanbakhsh
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul G ThomasDonald A Harn
Dec 18, 2003·Cellular Microbiology·Paul G Thomas, Donald A Harn

❮ Previous
Next ❯

Citations

Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niamh E ManganPadraic G Fallon
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Jan 6, 2006·Parasitology·D M McKay
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niamh E ManganPadraic G Fallon
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D TaylorJudith E Allen
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·He LiTan Jinquan
Aug 19, 2006·European Journal of Immunology·Harmjan KuipersBart N Lambrecht
Sep 13, 2006·Parasite Immunology·S M Kamal, K El Sayed Khalifa
Jun 29, 2007·Journal of Clinical Immunology·Shu-Chen WangJeng-Hsien Yen
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monique LafonHeinz Wiendl
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katie J MylonasJudith E Allen
Mar 18, 2009·European Journal of Immunology·Paola ZacconeAnne Cooke
Mar 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pamela M Odorizzi, E John Wherry
Apr 5, 2013·PLoS Neglected Tropical Diseases·Christine E FerragineStephen J Davies
Jan 28, 2015·Infection and Immunity·Catriona T PrendergastAdrian P Mountford
Apr 28, 2016·International Reviews of Immunology·Amin ZakeriAlireza Haghparast
Aug 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison C Billroth-MacLurgDeborah J Fowell
Feb 28, 2018·Frontiers in Immunology·Aditi SharmaMrigank Srivastava
Jul 11, 2018·International Journal of Molecular Sciences·Maike SperkUjjwal Neogi
Sep 27, 2006·The Journal of Experimental Medicine·Gordon J FreemanArlene H Sharpe
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel E Kaufmann, Bruce D Walker
Nov 23, 2005·The Journal of Experimental Medicine·Philip SmithPadraic G Fallon
Oct 1, 2011·Journal of Biomedicine & Biotechnology·Kimberly A HofmeyerXingxing Zang
Apr 5, 2007·European Journal of Immunology·Niamh E ManganPadraic G Fallon
Oct 22, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhugong LiuWilliam C Gause
Sep 27, 2012·The Journal of Pathology·Alain BeschinJo A Van Ginderachter
Nov 10, 2012·Seminars in Immunopathology·Keke FairfaxEdward J Pearce
May 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas LindenstrømPeter Andersen
Mar 22, 2013·PLoS Pathogens·Nienke van der WerfMatthew D Taylor
Feb 12, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanna JamonttPhilip Smith
Dec 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Obondo J SandeW Henry Boom
May 30, 2019·Infection and Immunity·Achilleas FloudasPadraic G Fallon
Dec 4, 2019·Frontiers in Immunology·Meijuan Zheng, Zhigang Tian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Philip SmithPadraic G Fallon
The Journal of Immunology : Official Journal of the American Association of Immunologists
Niamh E ManganPadraic G Fallon
The Journal of Immunology : Official Journal of the American Association of Immunologists
Niamh E ManganPadraic G Fallon
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Roland SchoopRudolf P Wüthrich
© 2022 Meta ULC. All rights reserved