Schistosomal egg granuloma-derived fibroblast-stimulating factor is apparently distinct from interleukin-1.

Infection and Immunity
S PrakashD J Wyler

Abstract

We have previously reported that egg granulomas isolated from livers of Schistosoma mansoni-infected euthymic mice in vitro elaborate a factor(s) that stimulates a variety of fibroblast responses including fibroblast proliferation and enhanced synthesis of extracellular matrix proteins. We have postulated that these factors play a role in the pathogenesis of hepatic fibrosis in schistosomiasis mansoni. Serum-free supernatants from egg granuloma cultures also stimulate thymocyte proliferation in an assay that defects interleukin-1 (IL-1). Thymocytes and fibroblasts are stimulated to proliferate by the same fractions of egg granuloma culture supernatant separated by gel filtration, isoelectric focusing, and ion-exchange chromatography. This suggested that granuloma-derived IL-1 is responsible for the observed fibroblast stimulation. Here we report that the ability of granuloma culture supernatants to stimulate the IL-1-sensitive D10.G4.1 cells but not fibroblasts is removed by treatment with immobilized anti-IL-1 antibody. We also observed that dialyzed culture supernatants from egg granulomas obtained from infected congenitally athymic (nude) mice also stimulate fibroblast proliferation. Treatment with anti-IL-1 antibody did not...Continue Reading

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Citations

Mar 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D M BissellF J Roll
Nov 11, 1998·DNA and Cell Biology·S Prakash, P W Robbins
Jun 1, 1990·Scandinavian Journal of Immunology·K ZwingenbergerA R Correia Dacal

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