Schistosome migration in primates: a study in the olive baboon (Papio anubis)

Transactions of the Royal Society of Tropical Medicine and Hygiene
R Alan WilsonG D Reid

Abstract

The migration of isotopically labelled schistosomula of Schistosoma mansoni from the skin to the hepatic portal system of baboons was tracked by autoradiography of compressed organ preparations. Passage of schistosomula from skin to lungs was rapid between days 2 and 5, 72% of applied parasites being detected in the lungs at the latter time. There was an equally rapid migration from lungs to liver, 60% of the adult worm burden having arrived by day 9. Perfusion data indicated a final maturation of not less than 78%. No evidence was found to support or refute a systemic phase of migration. Thus, in comparison to rodents, schistosome migration in baboons appears to be faster and more successful, possibly because the lungs do not represent a significant obstacle to migration.

References

Jan 1, 1978·Transactions of the Royal Society of Tropical Medicine and Hygiene·R F SturrockR Kimani
Nov 1, 1986·The American Journal of Tropical Medicine and Hygiene·P M KnopfD A Dean
May 1, 1988·The American Journal of Tropical Medicine and Hygiene·P S Coulson, R A Wilson

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Citations

Mar 7, 2009·Parasitology·R A Wilson
Sep 24, 2005·Parasite Immunology·S J JenkinsA P Mountford
Apr 24, 2004·Trends in Parasitology·Adrian P Mountford, Francois Trottein
Aug 28, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Luna de OliveiraJosé Valfrido de Santana
Jan 1, 1990·Parasitology Today·R A Wilson
Apr 3, 2020·PLoS Neglected Tropical Diseases·Catherine S NationPatrick J Skelly
Mar 26, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Thadzia Maria de Brito RamosVera Lúcia de Menezes Lima
May 7, 2021·Frontiers in Immunology·Emma L HoulderAndrew S MacDonald
Feb 15, 2003·Trends in Parasitology·Rachel S Curwen, R Alan Wilson

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